MODE OF ACTION OF CIS-DICHLORO-DIAMMINE PLATINUM(II) ON MOUSE EHRLICH ASCITES TUMOR-CELLS
MODE OF ACTION OF CIS-DICHLORO-DIAMMINE PLATINUM(II) ON MOUSE EHRLICH ASCITES TUMOR-CELLS
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DOI：
10.1016/0006-2952(76)90191-x
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发表时间：
1976-01-01
影响因子：
5.8
通讯作者：
BASSLEER, R
中科院分区：
文献类型：
--
作者：
HEINEN, E;BASSLEER, R
携带艾氏腹水瘤的小鼠接受1次腹腔注射。注射用顺式二氯二胺铂(II)、顺铂(II)。用细胞学和定量细胞化学方法对肿瘤细胞进行分析。顺铂(II)抑制细胞增殖。当有丝分裂开始时，通常会出现中期停滞。这种化合物阻止了G2期的细胞(相对于DNA的合成后)，但RNA和蛋白质的合成保持活跃，细胞变得巨大，并含有突出的核仁。后来，它们慢慢退化，腹水肿瘤趋于消失。肿瘤有时会恢复生长。
Mice bearing an Ehrlich ascites tumor received 1 i.p. injection of cis-dichlorodiammine platinum (II), cis-Pt (II). The tumor cells were analyzed with cytological and quantitative cytochemical methods. cis-Pt (II) inhibits cell multiplication. When mitosis begins, a block in metaphase usually occurs. This compound blocks the cells in G2 (postsynthesis as to DNA) but, RNA and protein synthesis remaining active, the cells become giant and contain prominent nucleoli. Later, they slowly degenerate and the ascites tumor tends to disappear. Tumor growth can sometimes resume.