UNALTERED ACONITASE ACTIVITY, BUT DECREASED COMPLEX-I ACTIVITY IN SUBSTANTIA-NIGRA PARS-COMPACTA OF PATIENTS WITH PARKINSONS-DISEASE
UNALTERED ACONITASE ACTIVITY, BUT DECREASED COMPLEX-I ACTIVITY IN SUBSTANTIA-NIGRA PARS-COMPACTA OF PATIENTS WITH PARKINSONS-DISEASE
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DOI：
10.1016/0304-3940(94)90372-7
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发表时间：
1994-03-14
影响因子：
2.5
通讯作者：
REICHMANN, H
中科院分区：
文献类型：
--
作者：
JANETZKY, B;HAUCK, S;REICHMANN, H
对7名死于帕金森氏病的患者的黑质致密部进行了铁依赖乌头酸酶的研究(反应I和II)。此外，我们还分析了呼吸链酶。虽然呼吸链的复合体I活性显著降低，但这一途径的其他酶没有改变。柠檬酸循环酶乌头酸酶(反应I和反应II)在患者和对照组之间没有差异。因此，这种对亚铁依赖和氧化敏感的酶不会受到帕金森病患者黑质中非生理性的高铁和“氧化应激”的影响。
Substantia nigra pars compacta of seven patients who had died of Parkinson's disease, has been investigated for the iron-depending aconitase (reactions I and II). In addition we analysed respiratory chain enzymes. While complex I activity of the respiratory chain was significantly reduced, other enzymes of this pathway were unaltered. The citric acid cycle enzyme aconitase (reactions I and II) showed no difference between patients and controls. Thus this ferrous iron dependent and oxidatively sensitive enzyme is not affected by the unphysiological high amount of ferric iron and the 'oxidative stress' present in substantia nigra of parkinsonian patients.