Changing to NIPT as a first-tier screening test and future perspectives: opinions of health professionals
Changing to NIPT as a first-tier screening test and future perspectives: opinions of health professionals
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DOI：
10.1002/pd.4697
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发表时间：
2015-12-01
影响因子：
3
通讯作者：
Henneman, Lidewij
中科院分区：
文献类型：
--
作者：
Tamminga, Saskia;van Schendel, Rachel V.;Henneman, Lidewij
目的探讨非侵入性产前检查(NIPT)在荷兰西部和北部地区受训后，对提供无创产前检查(NIPT)作为第一层筛查检查的意见，以及对潜在的更广泛的疾病范围的看法。方法对240名产科卫生专业人员进行问卷调查。结果大多数受访者(72%)赞成用NIPT取代早期妊娠联合检查(FCT)，但43%的受访者倾向于维持颈部透明测量。许多受访者认为，用NIPT取代FCT只会有好处(57%)，会导致更多的孕妇选择产前检查(69%)，并将简化咨询(47%)。观察到健康专业人员对咨询的态度不同。当考虑NIPT筛查范围更广的疾病时，大多数(92%)认为这应该包括以新生儿死亡为特征的疾病，而52%的受访者赞成对胎儿-母体风险因素进行测试。总体而言，46%的人认为筛查应该作为一份固定的障碍清单提供。结论大多数卫生专业人员倾向于NIPT而不是FCT，但更喜欢保持颈部半透明的测量。如果NIPT可以作为第一级筛查试验，仍有必要注意确保孕妇做出与产前筛查目标一致的知情决定。(C)2015年John Wiley&Sons，Ltd.
Objective The aim of this study was to investigate health professionals' opinions toward offering noninvasive prenatal testing (NIPT) as first-tier screening test regardless of pregnant women's risk, and toward a potential broader range of disorders.Methods A questionnaire completed by obstetric health professionals (n = 240) after an in-service NIPT training in the West and North of the Netherlands.Results The majority (72%) of respondents favored replacing first-trimester combined test (FCT) by NIPT, although 43% preferred to maintain nuchal translucency measurement. Many respondents believed that replacing FCT by NIPT would only have advantages (57%), would lead to more pregnant women opting for prenatal testing (69%), and would simplify counseling (47%). Differences in attitudes toward counseling between health professionals were observed. When considering NIPT to screen for broader range of disorders, the majority (92%) thought that this should include disorders characterized by neonatal death, whereas 52% of the respondents favored testing for fetomaternal risk factors. Overall, 46% thought screening should be offered as a fixed list of disorders.Conclusion Most health professionals favor NIPT instead of FCT but prefer to maintain nuchal translucency measurement. If NIPT becomes available as a first-tier screening test, attention remains necessary to ensure that pregnant women make well-informed decisions in line with the aim of prenatal screening. (C) 2015 John Wiley & Sons, Ltd.