ISOLATION AND ENVELOPE SEQUENCE OF A HIGHLY DIVERGENT HIV-1 ISOLATE - DEFINITION OF A NEW HIV-1 GROUP
ISOLATION AND ENVELOPE SEQUENCE OF A HIGHLY DIVERGENT HIV-1 ISOLATE - DEFINITION OF A NEW HIV-1 GROUP
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DOI：
10.1006/viro.1994.1640
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发表时间：
1994-11-15
期刊：
影响因子：
3.7
通讯作者：
CLAVEL, F
中科院分区：
文献类型：
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作者：
CHARNEAU, P;BORMAN, AM;CLAVEL, F
我们在这里报告的分离和信封序列的分歧HIV-1分离法国妇女艾滋病。这种病毒，HIV-1（VAU），与最近描述的爱沙尼亚病毒分离株HIV-1（ANT 70）和HIV-1（MVP 5180）密切相关，直到现在被命名为HIV-1亚型O。系统发育分析表明，这三种病毒彼此之间的距离相等，它们之间的相互分歧与更传统的HIV-1亚型之间的报道相似。因此，这三种病毒可以被包括在一个新的病毒组中，HIV-1 O组（外组），与其他HIV-1分离株的簇不同，我们将其称为M组（主要组）。HIV-1 O组目前正在非洲中西部出现，但其在欧洲的传播已经开始，（C）1994年学术出版社，Inc。
We report here the isolation and envelope sequence of a divergent HIV-1 isolate from a French woman with AIDS. This virus, HIV-1(VAU), is closely related to the recently described Cameroonian viral isolates HIV-1(ANT70), and HIV-1(MVP5180), until now designated HIV-1 subtype O. Phylogenetic analysis reveals that the three viruses are equidistant from one another and that their mutual divergence is similar to what has been reported between the more conventional HIV-1 subtypes. Therefore, these three viruses could be included in a new viral group, HIV-1 group O (outgroup), distinct from the cluster of other HIV-1 isolates, which we will refer to as group M (Major group). The HIV-1 group O is currently emerging in western central Africa but its spread in Europe has already started, (C) 1994 Academic Press, Inc.