Functional significance of Ca2+ in long-lasting fatigue of skeletal muscle
Functional significance of Ca2+ in long-lasting fatigue of skeletal muscle
复制标题
Ca2 在骨骼肌持久疲劳中的功能意义
DOI：
10.1007/s004210000275
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发表时间：
2000
影响因子：
3
通讯作者：
J. Lännergren
中科院分区：
文献类型：
--
作者：
H. Westerblad;J. Bruton;D. Allen;J. Lännergren
骨骼肌的反复激活会导致疲劳，这涉及到产生力量的能力降低以及缩短和松弛速度方面的收缩减慢。骨骼肌疲劳的一个重要组成部分是肌浆网（SR）Ca2+释放减少。在本综述中，我们将描述不同类型的疲劳诱导抑制SR钙释放。我们将关注一种被称为低频疲劳的SR Ca2+释放的长期失败，因为这种类型的疲劳可能与计算机工作者经历的肌肉功能障碍和慢性疼痛有关。奇怪的是，似乎从SR释放的Ca 2+，这是收缩所需的，实际上可能是负责SR Ca 2+释放在低频疲劳过程中的失败。我们还将讨论肌纤维的总体形态变化和SR Ca2+释放的长期失败之间的关系。最后，提出了一个连接肌肉细胞功能障碍和肌肉疼痛的模型。
Abstract Repeated activation of skeletal muscle causes fatigue, which involves a reduced ability to produce force and slowed contraction regarding both the speed of shortening and relaxation. One important component in skeletal muscle fatigue is a reduced sarcoplasmic reticulum (SR) Ca2+ release. In the present review we will describe different types of fatigue-induced inhibition of SR Ca2+ release. We will focus on a type of long-lasting failure of SR Ca2+ release which is called low-frequency fatigue, because this type of fatigue may be involved in the muscle dysfunction and chronic pain experienced by computer workers. Paradoxically it appears that the Ca2+ released from the SR, which is required for contraction, may actually be responsible for the failure of SR Ca2+ release during low-frequency fatigue. We will also discuss the relationship between gross morphological changes in muscle fibres and long-lasting failure of SR Ca2+ release. Finally, a model linking muscle cell dysfunction and muscle pain is proposed.