The site of a motor memory shifts with consolidation
The site of a motor memory shifts with consolidation
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DOI：
10.1523/jneurosci.2215-05.2005
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发表时间：
2005-08-31
影响因子：
5.3
通讯作者：
Broussard, DM
中科院分区：
文献类型：
--
作者：
Kassardjian, CD;Tan, YF;Broussard, DM
记忆巩固的基础是一个有争议的话题，特别是在运动记忆的情况下。一种观点认为，运动记忆在巩固过程中部分或全部转移到一个新的位置（“系统巩固”）。我们研究了这种可能性在一个原始的运动系统，前庭眼反射（VOR）。在VOR的简单电路中，存在相对较少的可能的存储器存储位置。我们用谷氨酸拮抗剂6-氰基-7-硝基喹喔啉-2，3-二酮（CNQX）部分阻断猫小脑皮质的兴奋性神经传递。如果在诱导VOR增益降低的条件下旋转60分钟后立即注射CNQX，则增益恢复到其基线值。表达的新的记忆也可以被破坏旋转在黑暗中，这表明巩固没有发生，然而，学习后，持续了3天，表达的学习变化减少只有轻微的封锁和旋转在黑暗中不受影响。我们对这些结果的解释是，学习可能最初发生在小脑皮层，在巩固过程中，运动记忆被转换为一个更分布式的表示，包括小脑皮层和另一个网站。
The basis for the consolidation of memory is a controversial topic, particularly in the case of motor memory. One view is that motor memory is transferred, partially or completely, to a new location during the consolidation process ("systems consolidation"). We investigated this possibility in a primitive motor system, the vestibulo-ocular reflex (VOR). In the simple circuitry of the VOR, there are relatively few possible storage sites for memory. We partially blocked excitatory neurotransmission in the cerebellar cortex of cats with the glutamate antagonist 6-cyano-7-nitroquinoxaline-2,3-dione ( CNQX). If CNQX was injected immediately after 60 min of rotation under conditions that induced a learned decrease in the gain of the VOR, gain was returned to its baseline value. Expression of the new memory could also be disrupted by rotation in darkness, suggesting that consolidation had not taken place; however, after learning had continued for 3 d, expression of the learned change was diminished only slightly by blockade and was unaffected by rotation in darkness. Our interpretation of these results is that learning may take place initially in the cerebellar cortex and that during consolidation, motor memories are converted to a more distributed representation that includes the cerebellar cortex and another site.