Spatio-temporal variation in the structure of a chromosomal polymorphism zone in the house mouse
Spatio-temporal variation in the structure of a chromosomal polymorphism zone in the house mouse
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DOI：
10.1038/hdy.2012.16
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发表时间：
2012-08-01
期刊：
影响因子：
3.8
通讯作者：
Ventura, J.
中科院分区：
文献类型：
--
作者：
Medarde, N.;Lopez-Fuster, M. J.;Ventura, J.
对西方家鼠（Mus musculus domesticus）罗伯逊（Rb）杂交区的结构进行了几项长期时间分析。然而，当研究周期之间的时间间隔太长时，可能会忽略对区域中逐渐或非常快速变化的检测。家鼠的巴塞罗那染色体多态性区覆盖巴塞罗那市周围约5000 km（2），并被40个染色体端着丝粒种群所包围。已报道了7种不同的中着丝粒细胞和小鼠，其二倍体数目在27至40条染色体之间，并有几种杂合状态的融合体（从1到7）。我们比较了目前（2008-2010年期间）和过去（1996-2000年期间）的结构，然后再更详细地研究其动态。结果表明，有没有Rb种族在这个地区，这是一致的建议，这个带可能是起源于原地，在一个初级的过渡方案。在当前时期，缺乏具有超过5个处于杂合状态的中着丝点的个体，这表明选择对这些小鼠起作用。相比之下，这种情况不会发生在杂合条件下少于5个融合的小鼠中。人类活动的变化可能影响亚群之间基因流动的动态，从而改变某些位点的染色体组成。虽然这些局部变化可能改变了某些稳心岩的倾斜趋势，但该带的一般交错结构在十年内没有显著变化。Heredity（2012）109，78-89; doi：10.1038/hdy.2012.16; 2012年4月25日在线发表
Several long-term temporal analyses of the structure of Robertsonian (Rb) hybrid zones in the western house mouse, Mus musculus domesticus, have been performed. Nevertheless, the detection of gradual or very rapid variations in a zone may be overlooked when the time elapsed between periods of study is too long. The Barcelona chromosomal polymorphism zone of the house mouse covers about 5000 km(2) around the city of Barcelona and is surrounded by 40 chromosome telocentric populations. Seven different metacentrics and mice with diploid numbers between 27 and 40 chromosomes and several fusions in heterozygous state (from one to seven) have been reported. We compare the present (period 2008-2010) and past (period 1996-2000) structure of this zone before examining its dynamics in more detail. Results indicate that there is not a Rb race in this area, which is consistent with the proposal that this zone was probably originated in situ, under a primary intergradation scenario. The lack of individuals with more than five metacentrics in heterozygous state in the current period suggests that selection acted against such mice. By contrast, this situation did not occur for mice with fewer than five fusions in heterozygous condition. Changes in human activity may affect the dynamics of gene flow between subpopulations, thus altering the chromosomal composition of certain sites. Although these local variations may have modified the clinal trend for certain metacentrics, the general staggered structure of the zone has not varied significantly in a decade. Heredity (2012) 109, 78-89; doi:10.1038/hdy.2012.16; published online 25 April 2012