Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.
Thymic dendritic cells traffic to thymi of allogeneic recipients and prolong graft survival.
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胸腺树突状细胞运输至同种异体受体的胸腺并延长移植物存活。
DOI：
10.1172/jci12142
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Theofilopoulos,ArgyriosN
中科院分区：
文献类型：
--
作者：
Duncan,StevenR;Capetanakis,NickolasG;Lawson,BrianR;Theofilopoulos,ArgyriosN
We have demonstrated that murine thymic dendritic cells (DCs) isolated from donor mice have the capability to home to thymi of fully allogeneic recipients after intravenous injections, where they induce T cell deletions and prolong donor-strain airway and skin graft survival. In contrast, infused splenic DCs immigrated poorly to thymi, and did not affect graft survival. These findings suggest that preferential homing may be an important mechanistic difference among subpopulations of DCs that mediate immune functions and illustrate a novel methodology that could have utility for induction of specific immunologic nonreactivity to allografts, or other disease-associated antigens.
