RAPID CLEARANCE OF A STRUCTURAL ISOMER OF BILIRUBIN DURING PHOTOTHERAPY
RAPID CLEARANCE OF A STRUCTURAL ISOMER OF BILIRUBIN DURING PHOTOTHERAPY
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DOI：
10.1172/jci113006
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发表时间：
1987-06-01
影响因子：
15.9
通讯作者：
SPECK, WT
中科院分区：
文献类型：
--
作者：
ENNEVER, JF;COSTARINO, AT;SPECK, WT
在新生儿黄疸的光疗过程中，胆红素转化为各种光产物。要确定这些光产物对胆红素清除的相对重要性，需要了解它们的排泄率。我们测量了胆红素的结构异构体，光胆红素，从九黄疸早产儿停止光疗后的血清中消失的速度。在所有研究的患者中，血清光胆红素的下降可以近似为一阶速率方程，半衰期为80至158分钟。这种消失速度比以前确定的其他主要胆红素光产物快得多。从光疗婴儿十二指肠抽取的胆汁样品中，发现光胆红素是主要的胆红素光产物，这些结果表明光胆红素的形成和排泄是光疗过程中胆红素消除的重要途径。
During phototherapy for neonatal jaundice, bilirubin is converted into a variety of photoproducts. Determination of the relative importance of these photoproducts to the elimination of bilirubin requires knowledge of their rates of excretion. We have measured the rate at which the structural isomer of bilirubin, lumirubin, disappeared from the serum of nine jaundiced premature infants after the cessation of phototherapy. In all patients studied, the decline in serum lumirubin could be approximated by a first-order rate equation with a half-life of 80 to 158 min. This rate of disappearance is much faster than that previously determined for the other major bilirubin photoproducts. In samples of bile aspirated from the duodenum of infants undergoing phototherapy, lumirubin was the principal bilirubin photoproduct found. These results indicate that formation and excretion of lumirubin is an important route for bilirubin elimination during phototherapy.