Multi-Bevel Needle Design Enabling Accurate Insertion in Biopsy for Cancer Diagnosis.
Multi-Bevel Needle Design Enabling Accurate Insertion in Biopsy for Cancer Diagnosis.
复制标题
DOI：
10.1109/tbme.2021.3054922
复制
发表时间：
2021-05
期刊：
影响因子：
--
通讯作者：
Shih A
中科院分区：
文献类型：
--
作者：
Li ADR;Liu Y;Plott J;Chen L;Montgomery JS;Shih A
为了获得明确的癌症诊断的可疑病变，准确的针头部署和充分的组织取样针活检是必不可少的。然而，目前的活检设备中的单斜面针在插入时往往会引起偏斜，可能导致病变误采样/欠采样和癌症误诊。本研究旨在揭示活检针的设计标准，使低偏转和充分的组织采样。为了了解不同针尖几何形状下针与组织的相互作用，首先建立了一种预测针偏转和组织变形的新模型。通过针偏转实验和离体组织活检进行模型验证。所开发的模型对针尖类型与由此产生的针挠度和组织采样长度的相关性显示出相当好的预测。一种新的多斜面针，其组织分离点位于针槽面下方，与目前的单斜面针相比，这种设计有效地减少了87%的偏转幅度，并延长了组织采样长度。本研究揭示了活检针的两个关键设计标准：1)针尖上的多个斜面可以产生力来平衡插入时的弯矩，从而使针挠度低；2)组织分离点应低于针槽面，以确保较长的组织采样长度。本研究中开发的方法和发现可作为概念验证，并可用于研究各种活检程序，以提高癌症诊断的准确性，以及其他需要准确插入针头的程序。
To obtain definitive cancer diagnosis for suspicious lesions, accurate needle deployment and adequate tissue sampling in needle biopsy are essential. However, the single-bevel needles in current biopsy devices often induce deflection during insertion, potentially causing lesion missampling/undersampling and cancer misdiagnosis. This study aims to reveal the biopsy needle design criteria enabling both low deflection and adequate tissue sampling. A novel model capable of predicting needle deflection and tissue deformation was first established to understand needle-tissue interaction with different needle tip geometries. Experiments of needle deflection and ex-vivo tissue biopsy were conducted for model validation. The developed model showed a reasonably good prediction on the correlation of needle tip type vs. the resultant needle deflection and tissue sampling length. A new multi-bevel needle with the tissue separation point below the needle groove face has demonstrated to be an effective design with an 87% reduction in deflection magnitude and equivalently long tissue sampling length compared to the current single-bevel needle. This study has revealed two critical design criteria for biopsy needles: 1) multiple bevel faces at the needle tip can generate forces to balance bending moments during insertion to enable a low needle deflection and 2) the tissue separation point should be below the needle groove face to ensure long tissue sampling length. The developed methodologies and findings in this study serve as proof-of-concept and can be utilized to investigate various biopsy procedures to improve cancer diagnostic accuracy as well as other procedures requiring accurate needle insertion.