Cytotoxic lissoclimide-type diterpenes from the molluscs Pleurobranchus albiguttatus and Pleurobranchus forskalii
Cytotoxic lissoclimide-type diterpenes from the molluscs Pleurobranchus albiguttatus and Pleurobranchus forskalii
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DOI：
10.1021/np0499620
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发表时间：
2004-08-01
影响因子：
5.1
通讯作者：
Valeriote, FA
中科院分区：
文献类型：
--
作者：
Fu, X;Palomar, AJ;Valeriote, FA
从菲律宾采集的白点侧鳃蚌（Pleurobrachusalbiguttatus）和福氏侧鳃蚌（P. forskalii）中分离得到3个新的氯代二萜化合物6-8，沿着分离得到5个已知的氯代二萜化合物1-5。这些二萜可能是软体动物赖以为生的海鞘的Lissoclinum种的代谢产物。新化合物的结构是通过解释它们的光谱数据确定的。在国家癌症研究所的60种肿瘤细胞系的筛选小组中发现化合物1和2是有效的细胞毒素，并显示出对黑素瘤的一些选择性。另外两个样本在软琼脂纸片扩散试验中表现出实体瘤选择性。
Three new chlorinated diterpenes, 6-8, along with five known ones, 1-5, were isolated from the molluscs Pleurobranchus albiguttatus and P. forskalii collected in the Philippines. These diterpenes are presumably metabolites of a Lissoclinum species of ascidian on which the molluscs have fed. The structures of the new compounds were determined by interpretation of their spectral data. Compounds 1 and 2 were found to be potent cytotoxins in the National Cancer Institute's screening panel of 60 tumor cell lines and showed some selectivity for melanomas. Two other samples exhibited solid tumor selectivity in a soft agar disk diffusion assay.