Diazoxide in treatment of primary pulmonary hypertension.
Diazoxide in treatment of primary pulmonary hypertension.
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二氮嗪治疗原发性肺动脉高压。
DOI：
10.1136/hrt.42.3.362
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发表时间：
1979
影响因子：
--
通讯作者：
J. S. Schroeder
中科院分区：
文献类型：
--
作者：
J. M. Rubino;J. S. Schroeder
先生，在阅读了Wang等人发表在《英国心脏杂志》（British Heart Journal, 1978, 40, 572-574）上的报告后，我们尝试了对原发性肺动脉高压患者使用二氮氧化合物的试验。结果提示在这类患者中谨慎使用该药。一名患有严重肺动脉高压的39岁女性，无明显原因，先前在心导管术中进行了不成功的氧、硝普塞、异丙肾上腺素和托唑啉试验。1978年8月，将二氮氧化合物注射到肺动脉主动脉，并在每次给药后5分钟采用Wang等人（1978）描述的程序进行血流动力学测量。结果列于表中。
Sir, After reading the report by Wang et al. in the British Heart Journal (1978, 40, 572-574), we attempted a trial of diazoxide in a patient with primary pulmonary hypertension. The outcome suggests caution in the use of this drug in such patients. A 39-year-old woman with severe pulmonary hypertension with no apparent cause had previously undergone unsuccessful trials of oxygen, nitroprusside, isoprenaline, and tolazoline during cardiac catheterisation. In August 1978 diazoxide was injected into the main pulmonary artery, and haemodynamic measurements were taken 5 minutes after each dose using the procedure described by Wang et al. (1978). The results are given in the Table.