Alcohol-triggered signs of migraine: An animal model
Alcohol-triggered signs of migraine: An animal model
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DOI：
10.3109/08990220.2016.1163258
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发表时间：
2016-01-01
影响因子：
0.9
通讯作者：
Masri, Radi
中科院分区：
文献类型：
--
作者：
Alabwah, Yaqoub;Ji, Yadong;Masri, Radi
我们描述了一种动物模型，其中饮酒可以引发偏头痛的特征。在长期植入横窦上方插管的大鼠中，我们将氯化钾（KCl）（或盐水）涂抹到脑膜上以使三叉血管传入敏感。我们使用条件性场所回避范式评估了重复施用 KCl 对动物行为的影响。在用 KCl 治疗的大鼠中，我们发现注射酒精（0.2 毫克/千克）而非盐水会导致出现脑外异常性疼痛和持续疼痛的迹象。
We describe an animal model where characteristics of migraine can be triggered by alcohol administration. In rats chronically implanted with a cannula overlying the transverse sinus, we applied potassium chloride (KCl) (or saline) to the meninges to sensitize trigeminovascular afferents. We assessed effects of repeated KCl application on animal behavior using conditioned place avoidance paradigm. In KCl-treated rats we discovered that alcohol injections (0.2 mg/kg), but not saline, resulted in the development of extracephalic allodynia and signs of ongoing pain.