Body Composition, Cardiorespiratory Fitness, and Low-Grade Inflammation in Middle-Aged Men and Women
Body Composition, Cardiorespiratory Fitness, and Low-Grade Inflammation in Middle-Aged Men and Women
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DOI：
10.1016/j.amjcard.2009.03.027
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发表时间：
2009-07-15
影响因子：
2.8
通讯作者：
Despres, Jean-Pierre
中科院分区：
文献类型：
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作者：
Arsenault, Benoit J.;Cartier, Amelie;Despres, Jean-Pierre
本研究的目的是确定内脏脂肪组织（AT）积累和心肺适应性对男性和女性炎症标志物变化的各自贡献。通过内脏AT（计算机断层扫描）和体能（身体工作能力测试）水平获得了c反应蛋白、肿瘤坏死因子- α、白细胞介素-6和脂联素的循环水平，这些样本涵盖了广泛的肥胖问题，包括健康男性（n = 120）和女性（n = 152）。根据每个炎症标志物的性别百分位数（0或1）制定炎症评分，得分范围从0（低）到4（高）。内脏AT与c反应蛋白和白细胞介素-6水平呈正相关（r >= 0.35, p < 0.0001），与脂联素呈负相关（r = -0.29, p .0001）
The objective of the present study was to determine the respective contributions of visceral adipose tissue (AT) accumulation and cardiorespiratory fitness to variation of inflammatory markers in men and women. Circulating levels of C-reactive protein, tumor necrosis factor-alpha, interleukin-6, and adiponectin were obtained with visceral AT (computed tomography) and fitness (physical working capacity test) levels in a sample of healthy men (n = 120) and women (n = 152) covering a wide range of adiposity. An inflammation score was developed based on gender-specific percentile values of each inflammatory marker (0 or 1), which yielded a score ranging from 0 (low) to 4 (high). Visceral AT was positively associated with C-reactive protein and interleukin-6 levels (r >= 0.35, p < 0.0001), but negatively associated with adiponectin (r = -0.29, p