The release of corticotrophin by anterior pituitary tissue in vitro.
The release of corticotrophin by anterior pituitary tissue in vitro.
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体外垂体前叶组织释放促肾上腺皮质激素。
DOI：
10.1139/o55-054
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发表时间：
1955
期刊：
影响因子：
--
通讯作者：
A. Schally
中科院分区：
文献类型：
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作者：
M. Saffran;A. Schally
大鼠垂体前叶组织在体外释放ACTH被用作检测刺激ACTH释放的因素的测试系统。结果表明： 1．单独添加肾上腺素或动脉醇无作用。2．单独使用下丘脑组织也是无效的。3．下丘脑组织与肾上腺素或动脉醇的结合使ACTH的释放增加约三倍。 4．大脑皮层可以替代下丘脑。5．肝脏不能替代神经组织；乙酰胆碱和血清素不能替代肾上腺素或动脉醇。6．垂体后叶组织加动脉肾上腺对 ACTH 释放的最大刺激（六到八倍）发生。 arterenol 可以被下丘脑或鞘氨醇取代，但不能被多巴胺（3,4-二羟基苯乙胺）取代，多巴胺在结构上与 arterenol 相似。7。垂体后叶可能参与垂体前叶-肾上腺皮质系统对应激的反应。
The release of ACTH by rat anterior pituitary tissue in vitro was used as a test system for the detection of factors that stimulate ACTH-release. The results indicate that:1. Epinephrine or arterenol, added by themselves, are without effect.2. Hypothalamic tissue alone is also ineffective.3. The combination of hypothalamic tissue with epinephrine or arterenol increases the release of ACTH about threefold.4. Brain cortex can replace hypothalamus.5. Liver cannot replace neural tissue; acetyl choline and serotonin cannot replace epinephrine or arterenol.6. The greatest stimulation of ACTH-release (six- to eight-fold) occurs with posterior pituitary tissue plus arterenol. The arterenol may be replaced by hypothalamus or sphingosine, but not by dopamine (3,4-dihydroxyphenylethylamine), which is structurally similar to arterenol.7. The posterior pituitary is probably involved in the response of the anterior pituitary–adrenocortical system to stress.