Temporal stability of multiple response systems to 7.5% carbon dioxide challenge.
Temporal stability of multiple response systems to 7.5% carbon dioxide challenge.
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DOI：
10.1016/j.biopsycho.2017.01.014
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发表时间：
2017-03
影响因子：
2.6
通讯作者：
Teachman BA
中科院分区：
文献类型：
--
作者：
Roberson-Nay R;Gorlin EI;Beadel JR;Cash T;Vrana S;Teachman BA
自我报告的焦虑和潜在的生理反应，保持吸入富含二氧化碳（CO2）的空气显示出作为恐慌反应和脆弱性的假定标志的希望。在低剂量、稳态CO2呼吸挑战过程中，缺乏反应系统的时间稳定性。在93名受试者中，对多个水平的结果进行了两次测量，间隔一周。与CO2前和恢复期相比，CO2呼吸期的稳定性最高，焦虑评分、呼吸频率、皮肤电导水平和心率显示出良好至极好的时间稳定性（ICC ≥ 0.71）。在CO2呼吸期间，与恐慌相关的认知症状（ICC = 0.58）比身体症状（ICC = 0.74）更不稳定。逃避/回避行为和DSM-5惊恐发作不稳定。还观察到任务阶段之间的大效应大小。总体而言，结果表明，在通过7.5% CO2进行呼吸刺激期间，多个结局的时间稳定性水平为良好-极佳。
Self-reported anxiety, and potentially physiological response, to maintained inhalation of carbon dioxide (CO2) enriched air shows promise as a putative marker of panic reactivity and vulnerability. Temporal stability of response systems during low-dose, steady-state CO2 breathing challenge is lacking. Outcomes on multiple levels were measured two times, one week apart, in 93 individuals. Stability was highest during the CO2 breathing phase compared to pre-CO2 and recovery phases, with anxiety ratings, respiratory rate, skin conductance level, and heart rate demonstrating good to excellent temporal stability (ICCs ≥ 0.71). Cognitive symptoms tied to panic were somewhat less stable (ICC = 0.58) than physical symptoms (ICC = 0.74) during CO2 breathing. Escape/avoidance behaviors and DSM-5 panic attacks were not stable. Large effect sizes between task phases also were observed. Overall, results suggest good-excellent levels of temporal stability for multiple outcomes during respiratory stimulation via 7.5% CO2.