Is it really a mismatch negativity? An assessment of methods for determining response validity in individual subjects
Is it really a mismatch negativity? An assessment of methods for determining response validity in individual subjects
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DOI：
10.1016/s0168-5597(97)00024-5
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
Nicol, T
中科院分区：
文献类型：
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作者：
McGee, T;Kraus, N;Nicol, T
收集了 86 名正常学龄儿童对合成语音音节 /wa/ 和 /ba/ 的两种变体的错配消极 (MMN) 反应。在刺激条件下分析响应的波形特征和统计特性，以评估确定个体响应有效性的方法。使用信号检测理论技术对方法进行比较。基于反应面积、起始潜伏期和持续时间测量的标准是反应有效性的最佳指标。另外一个有希望的有效性指标是基于 Z 变换的显着性区间，该 Z 变换是通过考虑潜在噪声分布的方差而确定的。个体响应与响应负性的总平均值和积分计算的相关性显示出稍低的 d' 值。利用响应次平均值的统计方法是响应有效性最差的指标。这些方法可能主要受到 MMN 与潜在生理噪声相比的信噪比的限制。信噪比的改善仍然是解释个体受试者 MMN 的一个重要因素。 (C) 1997 爱思唯尔科学爱尔兰有限公司
Mismatch negativity (MMN) responses were collected from 86 normal school-age children in response to synthesized speech syllables, /wa/ and two variants of /ba/. Waveform characteristics and statistical properties of the responses were analyzed across stimulus conditions in order to assess methods for determining response validity in individuals. Methods were compared using signal detection theory techniques. Criteria based on measurements of response area, onset latency, and duration were the best indicators of response validity. Also a promising indicator of validity was the interval of significance based on Z transformations determined by considering the variance of the underlying noise distribution. Correlations of individual responses with the grand average and integral calculations of the response negativity showed somewhat lower d' values. Statistical methods which utilized response subaverages were the poorest indicators of response validity. Likely the methods are limited primarily by the signal to noise ratio of the MMN compared to the underlying physiologic noise. improvement of the signal to noise ratio remains a significant factor in the interpretation of MMN for individual subjects. (C) 1997 Elsevier Science Ireland Ltd.