Is auditory processing measured by the N100 an endophenotype for psychosis? A family study and a meta-analysis
Is auditory processing measured by the N100 an endophenotype for psychosis? A family study and a meta-analysis
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DOI：
10.1017/s0033291723003409
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发表时间：
2023-11-24
影响因子：
6.9
通讯作者：
Bramon，Elvira
中科院分区：
文献类型：
--
作者：
Wang，Baihan;Otten，Leun J.;Bramon，Elvira
N100是一种早期的听觉事件相关电位，已被发现在精神病患者中发生改变。然而，目前还不清楚N100是否是一种在患者亲属中也发生改变的精神疾病内表型。方法我们使用听觉怪异范式进行了一项家庭研究，比较了243名精神病患者、86名未受影响的亲属和194名对照的N100波幅和潜伏期。然后，我们进行了系统的综述和随机影响的荟萃分析，汇集了我们的结果和之前发表的14项家庭研究。我们比较了999名患者、1192名亲属和1253名对照组的数据，以调查N100差异的证据和程度。结果在我们的家族研究中，患者与对照组相比，N100波幅降低，N100潜伏期延长，但在未受影响的亲属和对照组之间没有发现显著差异。Meta分析显示，两名精神病患者的N100波幅和N100潜伏期延迟均显著降低(标准化均数差[S.M.D.]=N100波幅和S.M.D.的−0.48。=0.43(对于N100延迟)及其亲属(s.m.d.=N100振幅和s.m.d的−0.19.=0.33表示N100延迟)。然而，排除受影响亲属的研究后，只有亲属的N100潜伏期变化仍然显著。结论精神病患者及其亲属都存在N100潜伏期的变化，尤其是延长的N100潜伏期，使N100成为一种有前景的精神病内表型。N100的这种变化可能反映了精神病病因基础上的早期听觉处理的变化。
BackgroundThe N100, an early auditory event-related potential, has been found to be altered in patients with psychosis. However, it is unclear if the N100 is a psychosis endophenotype that is also altered in the relatives of patients.MethodsWe conducted a family study using the auditory oddball paradigm to compare the N100 amplitude and latency across 243 patients with psychosis, 86 unaffected relatives, and 194 controls. We then conducted a systematic review and a random-effects meta-analysis pooling our results and 14 previously published family studies. We compared data from a total of 999 patients, 1192 relatives, and 1253 controls in order to investigate the evidence and degree of N100 differences.ResultsIn our family study, patients showed reduced N100 amplitudes and prolonged N100 latencies compared to controls, but no significant differences were found between unaffected relatives and controls. The meta-analysis revealed a significant reduction of the N100 amplitude and delay of the N100 latency in both patients with psychosis (standardized mean difference [s.m.d.] = −0.48 for N100 amplitude and s.m.d. = 0.43 for N100 latency) and their relatives (s.m.d. = − 0.19 for N100 amplitude and s.m.d. = 0.33 for N100 latency). However, only the N100 latency changes in relatives remained significant when excluding studies with affected relatives.ConclusionsN100 changes, especially prolonged N100 latencies, are present in both patients with psychosis and their relatives, making the N100 a promising endophenotype for psychosis. Such changes in the N100 may reflect changes in early auditory processing underlying the etiology of psychosis.