ATP-activated channels in excitable cells.
ATP-activated channels in excitable cells.
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可兴奋细胞中 ATP 激活的通道。
DOI：
10.1007/978-1-4615-7305-0_5
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Friel,DD
中科院分区：
文献类型：
--
作者：
Bean,BP;Friel,DD
越来越多的证据表明，ATP可能作为细胞外化学信使发挥作用，甚至可能是一种真正的神经递质。ATP被用作突触递质的最有力证据来自对交感神经传递到输精管和各种血管中平滑肌靶点的研究。例如，将ATP应用于大鼠或豚鼠的输精管肌肉，使肌肉去极化，并产生类似于神经刺激引起的抽搐。ATP诱导的去极化和神经诱发的兴奋性接点电位都可以被ATP的结构类似物如芳基叠氮基氨基丙酰基ATP（ANAPP 3）和（X，13）-亚甲基ATP抑制（Sneddon et 01.，1982年; Sneddon和Burnstock，1984年; Sneddon和Westfall，1984年）。最近，研究表明，离体输精管平滑肌细胞含有阳离子选择性通道，微摩尔浓度的ATP可打开这些通道（Nakazawa和Matsuki，1987; Friel，1988）。通道具有接近0 mV的反转电位，因此它们对细胞具有兴奋作用。似乎很可能是一个快速的，非肾上腺素能，非胆碱能传递的组成部分是由神经释放的A TP打开这些通道介导的。
There is increasing evidence that ATP may playa role as an extracellular chemical messenger, probably even a true neurotransmitter. The strongest evidence for ATP being used as a synaptic transmitter has come from studies on sympathetic transmission to smooth muscle targets in the vas deferens and various blood vessels. For example, ATP applied to rat or guinea pig vas deferens muscle depolarizes the muscle and produces a twitch like that elicited by nerve stimulation. Both the ATP-induced depolarization and the nerve-evoked excitatory junction potential can be inhibited by structural analogues of ATP like arylazido aminopropionyl ATP (ANAPP3) and (X, I3-methylene ATP (Sneddon et 01., 1982; Sneddon and Burnstock, 1984; Sneddon and Westfall, 1984). Recently, it has been shown that isolated vas deferens smooth muscle cells contain cation-selective channels that are opened by micromolar concentrations of ATP (Nakazawa and Matsuki, 1987; Friel, 1988). The channels have a reversal potential near 0 mV so that they have an excitatory effect on the cell. It seems very likely that a component of fast, nonadrenergic, noncholinergic transmission is mediated by nerve-released A TP opening these channels.