Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt
Convergent signal transduction pathways controlling cardiomyocyte survival and function: the role of PI 3-kinase and Akt
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DOI：
10.1016/j.yjmcc.2004.11.005
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发表时间：
2005-01-01
影响因子：
5
通讯作者：
Rosenzweig, A
中科院分区：
文献类型：
--
作者：
Matsui, T;Rosenzweig, A
在临床环境中有效的心脏保护不仅需要心肌细胞的存活，而且还需要保存功能。多种生长因子保护心脏免受缺血和其他损伤。虽然这些心脏保护因子的下游信号通路复杂，但磷脂酰肌醇3-激酶(PI-3-Kinase)及其下游效应因子的激活。丝氨酸-苏氨酸激酶Akt(或蛋白激酶B)，在许多情况下是一个共同的特征。在体外和体内对心肌细胞的遗传操作表明，该通路的急性激活可以促进心肌细胞的存活和功能。这里。我们综述了PI-3-激酶和Akt信号转导途径。重点放在它们在心肌细胞生长中的作用。生死存亡。和功能。最后，将考虑这些研究的临床意义。(C)2004爱思唯尔有限公司。保留所有权利。
Effective cardioprotection in clinical settings requires not only cardiomyocyte survival but also preservation of fonction. Multiple growth factors protect the heart from ischemic and other injury. While the downstream signaling pathways of these cardioprotective factors are complex, activation of phosphoinositide 3-kinase (PI 3-kinase) and its downstream effector. the serine-threonine kinase Akt (or Protein Kinase B), is a common feature in many cases. Genetic manipulations in cardiomyocytes both in vitro and in vivo suggest that acute activation of this pathway can promote both cardiomyocyte survival and function. Here. we review PI 3-kinase and Akt signaling. with a focus on their role in cardiomyocyte growth. survival. and function. Finally, the clinical implications of these studies will be considered. (C) 2004 Elsevier Ltd. All rights reserved.