Structure of naproxen, C14H14O3
Structure of naproxen, C14H14O3
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萘普生的结构，C14H14O3
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
E. Gabe
中科院分区：
文献类型：
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作者：
K. Ravikumar;S. Rajan;V. Pattabhi;E. Gabe
环加氧酶的有效抑制剂。Mr=230.25，单斜，P21, a= 13.3150(10), b = 5.7765 (4), c= 7.8732 (4) a, fl= 93.88(1)°，V= 604.2 (1) a3， Z= 2, Din= 1.25(2)（浮选），D~= 1.265 Mg m - 3,2 (Mo Ka 1) = 0.70926/~, #(Mo Ka) = 0.095 mm -1， F(000) = 244， T= 296 K，最终R(F) = 0.061。羧基相对于苯环的旋转，似乎与抗炎潜力有关，与已经报道的其他两种取代丙酸相似。萘基上的苯环呈5.2(2)°倾斜。介绍。标题化合物是负责前列腺素生物合成的环加氧酶的有效抑制剂，由马德拉斯基础医学研究所Natarajan博士获得。它在人体中表现出抗炎、镇痛和解热的活性（Goodman & Gilman, 1980）。对其结构进行分析，有助于建立丙酸衍生物的构效关系。
An effective inhibitor of cyclo-oxygenase. Mr=230.25 , monoclinic, P21, a= 13.3150(10), b = 5.7765 (4), c= 7.8732 (4)A, fl= 93.88 (1) °, V= 604.2 (1)A 3, Z= 2, Din= 1.25 (2) (flotation), D~= 1.265 Mg m -3, 2(Mo Ka 1) = 0.70926/~, #(Mo Ka) = 0.095 mm -1, F(000) = 244, T= 296 K, final R(F) = 0.061 for 1037 observed reflections. The rotation of the carboxyl group with respect to the benezene ring, which seems to be connected with anti-inflammatory potential, is similar to the other two substituted propionic acids already reported. The benzene rings in the naphthyl group are inclined at an angle of 5.2 (2) °. Introduction. The title compound, an effective inhibitor of the cyclo-oxygenase responsible for biosynthesis of prostaglandins, was obtained from Dr Natarajan, Institute of Basic Medical Sciences, Madras. It exhibits anti-inflammatory, analgesic and antipyretic activity in man (Goodman & Gilman, 1980). The analysis of its structure was undertaken to help to establish the structure-activity relationship in propionic acid derivatives.