Liposome encapsulated MnCl2 as a liver specific contrast agent for magnetic resonance imaging.
Liposome encapsulated MnCl2 as a liver specific contrast agent for magnetic resonance imaging.
复制标题
脂质体封装了 MnCl2 作为磁共振成像的肝脏特异性造影剂。
DOI：
10.1097/00004424-199005000-00012
复制
发表时间：
1990
影响因子：
6.7
通讯作者：
Magin,RL
中科院分区：
文献类型：
--
作者：
Niesman,MR;Bacic,GG;Wright,SM;Swartz,HJ;Magin,RL
我们检查了脂质体中包埋的 MnCl 2 作为磁共振成像肝脏特异性造影剂的有用性。毒性实验表明，成像实验的有效剂量比游离MnCl 2 的LD 50 低7～11倍。在植入肝肿瘤的大鼠中，脂质体包裹的MnCl 2 使肝脏舒张率增加2～3倍，而对肿瘤组织舒张率影响不大。植入肝脏的R3230腺癌在0.5T下获得的T 1 加权磁共振图像显示，注射游离MnCl 2 (25μmole/kg)后，正常肝脏和肿瘤组织的信号强度均增加。然而，注射脂质体封装的MnCl 2 (40 μmole/kg)后，肝脏的信号强度明显增加，而肿瘤组织的信号强度几乎没有变化。这些结果表明，脂质体封装的MnCl 2 具有作为肝脏特异性造影剂的优异潜力，用于改进肝转移的检测。
We examined the usefulness of MnCl 2 entrapped in liposomes as a liver specific contrast agent for magnetic resonance imaging. Toxicity experiments showed that the effective dose for imaging experiments was 7 to 11 times lower than the LD 50 of free MnCl 2. In rats with implanted liver tumors, liposome encapsulated MnCl 2 caused a two-to three-fold increase in the relaxation rate of the liver while having little effect on the relaxation rate of tumor tissue. T 1 weighted, magnetic resonance images obtained at 0.5 T of an R3230 adenocarcinoma implanted in the liver showed an increase in the signal intensity of both normal liver and tumor tissue after the injection of free MnCl 2 (25 μmole/kg). However, after the injection of liposome encapsulated MnCl 2 (40 μmole/kg) the liver exhibited a marked increase in signal intensity with little change in the signal intensity of the tumor tissue. These results suggest that liposome encapsulated MnCl 2 has excellent potential as a liver specific contrast agent for the improved detection of liver metastases.