Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses.
Profiles of cytokine and chemokine gene expression in human pulmonary epithelial cells induced by human and avian influenza viruses.
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DOI：
10.1186/1743-422x-7-344
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发表时间：
2010-11-26
期刊：
影响因子：
4.8
通讯作者：
Chan PK
中科院分区：
文献类型：
--
作者：
Lam WY;Yeung AC;Chu IM;Chan PK
流感大流行仍然是对人类健康的严重威胁。在这项研究中，使用基于人肺上皮细胞的体外系统比较了宿主细胞因子和趋化因子对高致病性禽流感H5 N1、低致病性禽流感H9 N2和季节性人流感H1 N1感染的反应。结果显示，H5 N1比H9 N2和H1N1更有效地诱导CXCL-10/IP-10、TNF-α和CCL-5/RANTES。总体而言，H9 N2的细胞因子/趋化因子谱与H1N1的细胞因子/趋化因子谱相似。有趣的是，只有H1N1，但没有一种禽类亚型可以诱导免疫调节细胞因子TGF-β2的持续升高。不同流感病毒感染后细胞因子/趋化因子的差异表达可能是临床结果的关键决定因素。使用这些细胞因子/趋化因子作为预后标志物或治疗靶点的潜力值得探索。
Influenza pandemic remains a serious threat to human health. In this study, the repertoire of host cellular cytokine and chemokine responses to infections with highly pathogenic avian influenza H5N1, low pathogenicity avian influenza H9N2 and seasonal human influenza H1N1 were compared using an in vitro system based on human pulmonary epithelial cells. The results showed that H5N1 was more potent than H9N2 and H1N1 in inducing CXCL-10/IP-10, TNF-alpha and CCL-5/RANTES. The cytokine/chemokine profiles for H9N2, in general, resembled those of H1N1. Of interest, only H1N1, but none of the avian subtypes examined could induce a persistent elevation of the immune-regulatory cytokine - TGF-β2. The differential expression of cytokines/chemokines following infection with different influenza viruses could be a key determinant for clinical outcome. The potential of using these cytokines/chemokines as prognostic markers or targets of therapy is worth exploring.