Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: Structure-activity studies
Quaternary ammonium functionalized poly(propylene imine) dendrimers as effective antimicrobials: Structure-activity studies
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DOI：
10.1021/bm0055495
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发表时间：
2000-09-01
影响因子：
6.2
通讯作者：
Cooper, SL
中科院分区：
文献类型：
--
作者：
Chen, CZS;Beck-Tan, NC;Cooper, SL
合成了季铵官能化聚丙基亚胺树状大分子，并用生物发光法对其抗菌性能进行了评价。这些季铵树状大分子是非常有效的杀菌剂。抗菌性能取决于树状大分子的大小、季铵基疏水链的长度和反阴离子。由于这些树状大分子具有良好的表征和单分散性，因此它们也可以作为研究结构-活性关系的有效体系。这些树状聚合物杀菌剂的抗菌性能与分子量呈抛物线型依赖关系，这与传统聚合物杀菌剂的钟形分子量依赖关系不同。对季铵盐疏水链结构的依赖与传统聚合物杀菌剂相似，呈抛物线关系，其中携带C-10疏水分子的树状聚合物杀菌剂最有效。这些新型溴化物阴离子杀菌剂的抗菌性能比氯离子杀菌剂更强。由超支化聚合物衍生的杀菌剂也被合成，但发现其有效性较低。
Quaternary ammonium functionalized poly(propyleneimine) dendrimers were synthesized and their antibacterial properties were evaluated using a bioluminescence method. These quaternary ammonium dendrimers are very potent biocides. The antibacterial properties depend on the size of the dendrimer, the length of hydrophobic chains in the quaternary ammonium groups, and the counteranion. Since these dendrimers are well characterized and monodisperse, they also serve as an effective system to study the structure-activity relationship. The antimicrobial properties of these dendrimer biocides have a parabolic dependence on molecular weight, which is different from the bell-shaped molecular weight dependence of conventional polymer biocides. The dependence on the hydrophobic chain of the quaternary ammonium structure is similar to conventional polymer biocides, and shows a parabolic relationship with dendrimer biocides carrying C-10 hydrophobes the most potent. The antimicrobial properties of these novel biocides with bromide anions are more potent than those with chloride anions. Biocides derived from hyperbranched polymers were also synthesized and found to possess somewhat lower effectiveness.