Addressing the challenges of adherence
Addressing the challenges of adherence
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DOI：
10.1097/00126334-200202011-00002
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发表时间：
2002-02-01
期刊：
影响因子：
--
通讯作者：
Bartlett, JA
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文献类型：
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作者：
Bartlett, JA
坚持抗逆转录病毒治疗是治疗成功的关键决定因素。研究明确表明，依从性与艾滋病毒感染和疾病患者的血浆艾滋病毒RNA水平、CD4细胞计数和死亡率之间存在密切关联。维持病毒学抑制需要大于或等于95%的依从性。然而，实际的依从率往往要低得多；大多数研究表明，40%到60%的患者是这样
Adherence to antiretroviral therapy is a crucial determinant of treatment success. Studies have unequivocally demonstrated the close association between adherence and plasma HIV RNA levels, CD4 cell counts, and mortality in patients with HIV infection and disease. Adherence levels of greater than or equal to95% are required to maintain virologic suppression. However, actual adherence rates are often far lower; most studies show that 40% to 60% of patients are