Site of action of vasopressin in causing corticotropin release.
Site of action of vasopressin in causing corticotropin release.
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加压素引起促肾上腺皮质激素释放的作用位点。
DOI：
10.1210/endo-79-2-328
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发表时间：
1966
期刊：
影响因子：
4.8
通讯作者：
F. Yates
中科院分区：
文献类型：
--
作者：
G. Hedge;M. Yates;R. Marcus;F. Yates
本文比较了赖氨酸加压素和猪脑垂体提取物的促肾上腺皮质激素释放特性，并将其注射到地塞米松处理的大鼠下丘脑和腺垂体。在所有病例中，用于中心注射的剂量都低于能够导致静脉注射后肾上腺皮质酮分泌增加的最小剂量，因此可以排除促肾上腺皮质激素(ACTH)效应或ACTH污染作为中心注射后肾上腺皮质酮分泌增加的原因。当加压素被放置在下丘脑的正中隆起时，它会刺激ACTH的广泛释放，脑下垂体提取物也是如此。下丘脑腺垂体内注射这两种物质时，加压素引起的ACTH释放比下丘脑注射后明显减少，而提取物引起的ACTH释放更多。在这两个部位注射加压素后，吗啡都能抑制ACTH的释放。
The corticotropin-releasing properties of lysine vasopressin and that of a porcine pituitary extract were compared by means of injections into hypothalamic sites or into the adenohypophysis of dexamethasone-pretreated rats of both sexes. In all cases the doses used for central injections were below the minimal dose capable of causing an increase in adrenal secretion of corticosterone after intravenous injection, so that corticotropin (ACTH-like) effects or contamination by ACTH could be excluded as a cause of increased adrenal secretion of corticosterone after the central injections. Vasopressin provoked extensive release of ACTH when it was placed in the median eminence of the hypothalamus, as did the pituitary extract. When the 2 substances were tested by intra-adenohypophysial injection, the vasopressin caused much less ACTH release and the extract caused more ACTH release than observed after intrahypothalamic injections. Morphine abolished the ACTH release after vasopressin injections at either site, ...