Update on the role of p75NTR in neurological disorders: A novel therapeutic target.
Update on the role of p75NTR in neurological disorders: A novel therapeutic target.
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DOI：
10.1016/j.biopha.2015.10.010
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发表时间：
2015-12
期刊：
影响因子：
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通讯作者：
Ya-Hai Shu;Xiu-Min Lu;Jing-Xiang Wei;Lan Xiao;Yong-Tang Wang
中科院分区：
文献类型：
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作者：
Ya-Hai Shu;Xiu-Min Lu;Jing-Xiang Wei;Lan Xiao;Yong-Tang Wang
p75神经营养因子受体（p75NTR）作为一种低亲和力神经营养因子受体，是一种跨膜受体，参与多种细胞反应，包括细胞凋亡、存活、轴突生长、迁移和细胞周期阻滞，其可能与一些神经系统疾病有关，如阿尔茨海默病（AD）、精神分裂症、重度抑郁症（MDD）、创伤后应激障碍（PTSD）、肌萎缩侧索硬化症（ALS）和帕金森病（PD）。事实上，在过去十年中的一系列研究已经证明，p75NTR信号转导在神经系统疾病的大多数方面起着关键作用。尽管现有的研究资料有限，但本文仍试图总结p75 NTR与多种神经系统疾病的关系，并试图进一步阐明其可能的机制，为神经系统疾病的治疗提供新的靶点。
As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a transmembrane receptor involved in a diverse array of cellular responses, including apoptosis, survival, neurite outgrowth, migration, and cell cycle arrest, which may be related to some neurological disorders, such as Alzheimer’s disease (AD), schizophrenia, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Indeed, a series of studies during the last decade has demonstrated that the p75NTR signaling plays key roles in most aspects of the neurological disorder diseases. In spite of the limited information available, this review still tried to summary the relationship between p75NTR and diverse neurological disorder diseases, and tried to further clarify the possible mechanism, which may provide a novel therapeutic target for the treatment of neurological disorders.