Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease.
Peptides and proteins in plasma and cerebrospinal fluid as biomarkers for the prediction, diagnosis, and monitoring of therapeutic efficacy of Alzheimer's disease.
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DOI：
10.1016/j.bbadis.2008.07.008
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发表时间：
2008-10
影响因子：
6.2
通讯作者：
Butterfield, D. Allan
中科院分区：
文献类型：
--
作者：
Aluise, Christopher D.;Sowell, Rena A.;Butterfield, D. Allan
阿尔茨海默病(AD)影响着全球数百万人。更早地发现和/或诊断AD将允许更早的干预，可以想见，这可能会延缓这种痴呆障碍的进展。为了实现这一目标，需要可靠和特异的生物标志物。生物标志物是多维的，有可能在AD的各个方面提供帮助，如诊断预测、疾病阶段评估、与正常认知控制和其他形式的痴呆的区别以及AD药物的治疗效果。到目前为止，生物标记物的研究主要集中在血浆和脑脊液(CSF)，这两种体液被认为含有AD生物标记物的最丰富来源。脑脊液是围绕中枢神经系统(CNS)的液体，是脑部病理最具指标性的液体。血浆含有从外周影响大脑过程的蛋白质，以及从大脑输出的蛋白质/多肽；由于样本采集过程简单且非侵入性，这种液体将是发现生物标记物的理想选择。然而，生物标志物的发现将导致脑脊液、血浆和其他液体(如尿液)的组合，以达到上述目的，这似乎是合理的。本文综述了脑脊液、血浆和尿液中可作为AD生物标志物的蛋白质和多肽的研究进展。
Alzheimer’s disease (AD) affects millions of persons worldwide. Earlier detection and/or diagnosis of AD would permit earlier intervention, which conceivably could delay progression of this dementing disorder. In order to accomplish this goal, reliable and specific biomarkers are needed. Biomarkers are multidimensional and have the potential to aid in various facets of AD such as diagnostic prediction, assessment of disease stage, discrimination from normally cognitive controls as well as other forms of dementia, and therapeutic efficacy of AD drugs. To date, biomarker research has focused on plasma and cerebrospinal fluid (CSF), two bodily fluids believed to contain the richest source of biomarkers for AD. CSF is the fluid surrounding the central nervous system (CNS), and is the most indicative obtainable fluid of brain pathology. Blood plasma contains proteins that affect brain processes from the periphery, as well as proteins/peptides exported from the brain; this fluid would be ideal for biomarker discovery due to the ease and non-invasive process of sample collection. However, it seems reasonable that biomarker discovery will result in combinations of CSF, plasma, and other fluids such as urine, to serve the aforementioned purposes. This review focuses on proteins and peptides identified from CSF, plasma, and urine that may serve as biomarkers in AD.
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影响因子：
17.7
作者：
Buerger, K;Zinkowski, R;Hampel, H
通讯作者：
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影响因子：
30.8
作者：
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DOI：
10.1124/jpet.104.075408
发表时间：
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影响因子：
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DOI：
10.1124/jpet.104.081174
发表时间：
2005-05-01
影响因子：
3.5
作者：
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通讯作者：
Atack, JR