Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory.
Differential effects of selective immunotoxic lesions of medial septal cholinergic cells on spatial working and reference memory.
复制标题
内侧间隔胆碱能细胞选择性免疫毒性损伤对空间工作和参考记忆的不同影响。
DOI：
10.1037//0735-7044.110.5.1181
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发表时间：
1996
影响因子：
1.9
通讯作者：
McNaughton,BL
中科院分区：
文献类型：
--
作者：
Shen,J;Barnes,CA;Wenk,GL;McNaughton,BL
在训练执行两种版本的放射状 8 臂迷宫任务的大鼠中，检查了对胆碱能神经元具有选择性的毒素 192 IgG-皂草素注射到内侧隔膜的效果。首先训练大鼠执行一项任务，在第 4 个正确的手臂选择和使用所有 8 个手臂之间施加不同的延迟（0、1、2 分钟）。与对照组相比，受损大鼠在前 4 个选择中犯的错误明显更多，延迟后错误也明显更多；然而，这种效果并不依赖于延迟。然后，老鼠接受了这个 8 臂迷宫任务的不同版本的训练，在其中它们学会了避开 2 条从未被诱饵的臂。获得这项任务没有治疗效果。这些数据与以下假设一致：胆碱能投射到海马体有助于将信息采集到负责所访问位置的短期记忆（空间工作记忆）的系统中，但不参与该信息的保留。它似乎在地点-非奖励关联（空间参考记忆）的获取或保留中也没有发挥任何作用。（PsycINFO 数据库记录 (c) 2016 APA，保留所有权利）
The effect of injection into the medial septum of a toxin selective for cholinergic neurons, 192 IgG-saporin, was examined in rats trained to perform 2 versions of the radial 8-arm maze task. Rats were first trained to perform a task with varying delays (0, 1, 2 min) imposed between the 4th correct arm choice and access to all 8 arms. Lesioned rats made significantly more errors in the first 4 choices compared with controls and significantly more errors after delays; however, this effect was not delay dependent. Rats were then trained on a different version of this 8-arm maze task in which they learned to avoid 2 arms that were never baited. There was no treatment effect on acquisition of this task. These data are consistent with the hypothesis that the cholinergic projection to the hippocampus facilitates the acquisition of information into the system responsible for short-term memory for locations visited (spatial working memory) but is not involved in retention of this information. It also appears to play no role in either the acquisition or retention of place-nonreward associations (spatial reference memory).(PsycINFO Database Record (c) 2016 APA, all rights reserved)