Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography
Identification of imaging features that determine quality and repeatability of retinal capillary plexus density measurements in OCT angiography
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DOI：
10.1136/bjophthalmol-2017-310700
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发表时间：
2018-04-01
影响因子：
4.1
通讯作者：
Cheung, Gemmy C. M.
中科院分区：
文献类型：
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作者：
Fenner, Beau J.;Tan, Gavin S. W.;Cheung, Gemmy C. M.
目的光学相干断层扫描血管造影术（OCT-A）可以快速、无创地定量检测不同疾病状态下视网膜毛细血管丛密度。本研究旨在确定影响OCT-A测量结果重复性的关键特征。方法我们在44例受试者的44只健康眼睛中获得了OCT-A图像，每只眼睛均使用Topcon DRI OCT Triton成像系统成像。利用内置的视网膜浅丛和深丛工具，获得以中心凹为中心的1.5mm半径内的视网膜旁血管密度。通过组内相关性（ICC）和平均变异确定血管密度的重复性。我们评估了几个图像参数，以确定它们对两个毛细血管丛中血管密度测量重复性的影响。结果受试者的平均年龄为70.29.2岁，其中64%为男性。第一次和第二次访视时，浅表神经丛的平均筋膜旁血管密度测量值分别为53.3 +/-11.1和53.3 +/- 10.3，深神经丛为27.3 +/-8.59和27.0 +/- 8.78。ICC分析表明，高精细血管的可见性，没有运动伪影和软件衍生的图像质量得分为60或以上是必要的，以获得良好的（ICC>0.6）或优秀的（ICC>0.75）replication.Conclusions我们的研究确定了成像参数，确定定量视网膜血管密度测量的可重复性。这些发现对于确定OCT-A图像是否可用于准确评估视网膜血管密度的连续变化具有重要意义。
Purpose Optical coherence tomography angiography (OCT-A) potentially allows for rapid and non-invasive quantification of retinal capillary plexus density in various disease states. This study aims to identify the key features that influenced the repeatability of OCT-A measurements.Methods We obtained OCT-A images on two separate visits in 44 healthy eyes from 44 subjects, each imaged with using the Topcon DRI OCT Triton imaging system. The parafoveal vessel density within a 1.5mm radius centred over the fovea was obtained with the built-in tool for the superficial and deep retinal plexuses. Repeatability of vessel density was determined by intraclass correlation (ICC) and mean variation. We evaluated several image parameters to determine their influence on the repeatability of vessel density measurement in each of the two capillary plexuses.Results The mean age of the subjects was 70.29.2 years, with 64% males. Mean parafoveal vessel density measurements for the first and second visits were 53.3 +/- 11.1and 53.3 +/- 10.3 for the superficial plexus and 27.3 +/- 8.59and 27.0 +/- 8.78 for the deep plexus. ICC analyses demonstrated that high fine vessel visibility, the absence of motion artefact and software-derived image quality score of 60 or above were necessary to obtain a good (ICC>0.6) or excellent (ICC>0.75) repeatability.Conclusions Our study identified the imaging parameters that determined the repeatability of quantitative retinal vessel density measurements. These findings have implications in determining if OCT-A images can be used to accurately evaluate serial changes in retinal vessel density.