Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.
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SIRT3 线粒体脱乙酰酶在细胞生理学、癌症和神经退行性疾病中的功能。
DOI：
10.1111/acel.12538
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发表时间：
2017-02
期刊：
影响因子：
7.8
通讯作者：
Kim KH
中科院分区：
文献类型：
--
作者：
Ansari A;Rahman MS;Saha SK;Saikot FK;Deep A;Kim KH
在哺乳动物中，已鉴定出称为III类组蛋白去乙酰化酶的沉默调节蛋白家族的七个成员的特征性特征。这些独特的特征包括它们分布或定位的组织、酶活性、分子功能和参与疾病。在sirtuin成员中，SIRT 3因其在癌症遗传学、衰老、神经退行性疾病和抗应激方面的作用而备受关注。SIRT3通过线粒体酶的去乙酰化和乙酰化来控制应激条件（如禁食和运动）期间的能量需求以及代谢。SIRT3以其消除活性氧物质和防止癌细胞发展或凋亡的能力而闻名。这篇综述文章对SIRT 3的许多（值得注意的）分子功能及其对癌细胞和各种疾病（包括亨廷顿病、肌萎缩性侧索硬化症和阿尔茨海默病）的影响进行了全面综述。
In mammals, seven members of the sirtuin protein family known as class III histone deacetylase have been identified for their characteristic features. These distinguished characteristics include the tissues where they are distributed or located, enzymatic activities, molecular functions, and involvement in diseases. Among the sirtuin members, SIRT3 has received much attention for its role in cancer genetics, aging, neurodegenerative disease, and stress resistance. SIRT3 controls energy demand during stress conditions such as fasting and exercise as well as metabolism through the deacetylation and acetylation of mitochondrial enzymes. SIRT3 is well known for its ability to eliminate reactive oxygen species and to prevent the development of cancerous cells or apoptosis. This review article provides a comprehensive review on numerous (noteworthy) molecular functions of SIRT3 and its effect on cancer cells and various diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease.