Taurospongin A, a novel acetylenic fatty acid derivative inhibiting DNA polymerase beta and HIV reverse transcriptase from sponge Hippospongia sp.
Taurospongin A, a novel acetylenic fatty acid derivative inhibiting DNA polymerase beta and HIV reverse transcriptase from sponge Hippospongia sp.
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DOI：
10.1021/jo970206r
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发表时间：
1997-06-13
影响因子：
3.6
通讯作者：
Kobayashi, J
中科院分区：
文献类型：
--
作者：
Ishiyama, H;Ishibashi, M;Kobayashi, J
从冲绳海海绵中分离得到一种新型的含乙炔的天然产物——牛磺酸A(1)，该产物由一个牛磺酸和两个脂肪酸残基组成，并通过光谱数据和化学方法对其结构进行了鉴定。牛磺酸海绵蛋白A(1)对DNA聚合酶β和HIV逆转录酶具有较强的抑制活性。通过合成降解产物1的MTPA酯，确定了牛磺酸海绵蛋白A(1)的绝对构型为3R、7S和9R。
Taurospongin A (1), a novel acetylene-containing natural product consisting of a taurine and two fatty acid residues, has been isolated from the Okinawan marine sponge Hippospongia sp. and its structure elucidated by spectral data and chemical means. Taurospongin A (1) exhibited potent inhibitory activity against DNA polymerase beta and HIV reverse transcriptase. The absolute configurations of taurospongin A (1) were established to be 3R, 7S, and 9R by synthesis of the MTPA ester of a degradation product of 1.