Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial.
Community-based trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial.
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DOI：
10.1186/1745-6215-9-73
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发表时间：
2008-12-10
期刊：
影响因子：
2.5
通讯作者：
Hay, Phillip
中科院分区：
文献类型：
--
作者：
Oakeshott, Pippa;Kerry, Sally;Hay, Phillip
背景：盆腔炎性疾病常见，可导致输卵管因素不孕、宫外孕或慢性盆腔疼痛。尽管英国政府在国家衣原体筛查计划上投入了大量资金，但其益处的证据仍然存在争议。这项试验的主要目的是调查筛查和治疗衣原体感染是否在12个月内降低了产后应激障碍的发生率。第二个目标是对细菌性阴道病(BV)在产后疼痛和衣原体感染的自然病史中的作用进行探索性研究。设计：随机对照试验，12个月后进行随访。非医疗保健场所：大伦敦地区20所大学和继续教育学院的公共休息室和演讲厅。方法：对2500名性行为活跃的女学生进行性健康问卷调查，并提供自制的阴道拭子和涂片。干预：对干预妇女的阴道拭子用聚合酶链式反应(PCR)检测衣原体，感染的转诊治疗。对照妇女的阴道拭子在一年后被储存和分析。对阴道涂片进行革兰氏染色和BV分析。主要结果衡量：干预组和对照组12个月以上的临床盆腔积液发生率。将通过问卷调查和记录搜索来确定可能的PID病例。诊断的确认将由三名独立研究人员通过详细审查医疗记录来完成，对妇女是在干预组还是对照组视而不见。TRIAL注册：临床试验NCT 00115388。
BACKGROUND: Pelvic inflammatory disease (PID) is common and can lead to tubal factor infertility, ectopic pregnancy or chronic pelvic pain. Despite major UK government investment in the National Chlamydia Screening Programme, evidence of benefit remains controversial. The main aim of this trial was to investigate whether screening and treatment of chlamydial infection reduced the incidence of PID over 12 months. Secondary aims were to conduct exploratory studies of the role of bacterial vaginosis (BV) in the development of PID and of the natural history of chlamydial infection.DESIGN: Randomised controlled trial with follow up after 12 months. SETTING NON-HEALTHCARE: Common rooms and lecture theatres at 20 universities and further education colleges in Greater London.PARTICIPANTS: 2500 sexually active female students were asked to complete a questionnaire on sexual health and provide self-administered vaginal swabs and smears.INTERVENTION: Vaginal swabs from intervention women were tested for chlamydia by polymerase chain reaction (PCR) and those infected referred for treatment. Vaginal swabs from control women were stored and analysed after a year. Vaginal smears were Gram stained and analysed for BV.MAIN OUTCOME MEASURE: Incidence of clinical PID over 12 months in intervention and control groups. Possible cases of PID will be identified from questionnaires and record searches. Confirmation of the diagnosis will be done by detailed review of medical records by three independent researchers blind to whether the woman is in intervention or control group.TRIAL REGISTRATION: Clinical Trials NCT 00115388.