Deep brain stimulation for essential tremor
Deep brain stimulation for essential tremor
复制标题
DOI：
10.1212/wnl.46.4.1150
复制
发表时间：
1996-04-01
期刊：
影响因子：
9.9
通讯作者：
Koller, WC
中科院分区：
文献类型：
--
作者：
Hubble, JP;Busenbark, KL;Koller, WC
我们研究了脑深部电刺激（DBS）治疗原发性震颤（ET）的效果和安全性。10名患有致残性药物难治性震颤的ET患者在左侧Vim丘脑核中接受了DBS电极导线的立体定向植入，并完成了6个月的随访。在基线、1个月、3个月和6个月随访时进行临床震颤评定量表和残疾评估。据受试者报告，在穿衣、饮水、进食、洗澡和书写方面都有显著改善。震颤的严重程度，书写，倾倒，螺旋和线条画显着改善，由检查员评定。在6个月的随访期内持续改善。尽管该组总体残疾显着减轻，但一名因书写而加剧手指震颤的受试者的残疾状态没有变化。在这项为期6个月的开放标签研究中，DBS在减少ET患者震颤和功能性残疾方面有效且安全。
We examined the effects and safety of deep brain stimulation (DBS) as a treatment for essential tremor (ET). Ten ET patients with disabling medication-refractory tremor underwent stereotactic implantation of a DBS lead in the left Vim thalamic nucleus and completed a 6-month follow-up. The Clinical Tremor Rating Scale and disability assessments were performed at baseline, 1-, 3-, and 6-month follow-up. There were significant improvements in dressing, drinking, eating, bathing, and handwriting as reported by the subjects. Tremor severity, writing, pouring, and spiral and line drawing were significantly improved as rated by the examiner. Improvements persisted through the 6-month follow-up period. Although global disability significantly lessened in the group as a whole, one subject with hand-finger tremor accentuated by writing had no change in disability status. In this 6-month open-label study, DBS was effective and safe in reducing tremor and functional disability in ET.