Modular Synthesis of Optically Active Tröger's Base Analogues.
Modular Synthesis of Optically Active Tröger's Base Analogues.
复制标题
光学活性 Tröger 基本类似物的模块化合成。
DOI：
10.1002/cplu.201300295
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发表时间：
2013
期刊：
影响因子：
3.4
通讯作者：
J. Cvengroš
中科院分区：
文献类型：
--
作者：
T. Kamiyama;M. S. Özer;Elisabeth Otth;J. Deska;J. Cvengroš
For the first time, enantioselective catalysis was applied for the preparation of Tröger's base derivatives affording N-stereogenic building blocks not only in excellent enantiomeric purity but also in an easily scalable fashion. Enzymatic kinetic resolution proved efficient to yield functionalized Tröger's bases, which can be subsequently modified by various chemical methods without any erosion of stereogenic information. In concert with a preparatively convenient protocol for the synthesis of the racemic substrates from commercially available anilines, a highly practicable and flexible route towards a wide range of enantiopure Tröger's base analogues is provided.
影响因子：
2.1
作者：
Fors BP;Dooleweerdt K;Zeng Q;Buchwald SL
通讯作者：
Buchwald SL