An Extremely Facile Synthesis of Furans, Pyrroles, and Thiophenes by the Dehydrative Cyclization of Propargyl Alcohols
An Extremely Facile Synthesis of Furans, Pyrroles, and Thiophenes by the Dehydrative Cyclization of Propargyl Alcohols
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DOI：
10.1021/ol901901m
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发表时间：
2009-10-15
期刊：
影响因子：
5.2
通讯作者：
Marques, Emerson Finco
中科院分区：
文献类型：
--
作者：
Aponick, Aaron;Li, Chuan-Ying;Marques, Emerson Finco
呋喃、吡咯和噻吩类化合物可通过金催化的容易获得的杂原子取代的炔丙醇的脱水环化反应有效地合成。该反应快速、高产率、操作简单，在开瓶条件下几分钟内即可得到基本上纯净的芳香族杂环，催化剂负载量低至0.05摩尔%。
Furans, pyrroles, and thiophenes are efficiently prepared by gold-catalyzed dehydrative cyclizations of readily available, heteroatom-substituted propargylic alcohols. The reactions are rapid, high-yielding, and procedurally simple, giving essentially pure aromatic heterocycles in minutes under open-flask conditions with catalyst loadings as low as 0.05 mol %.