Evaluation of serum gamma-glutamyl transferase as a screening method for excessive alcohol consumption during pregnancy.
Evaluation of serum gamma-glutamyl transferase as a screening method for excessive alcohol consumption during pregnancy.
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血清γ-谷氨酰转移酶作为妊娠期过量饮酒筛查方法的评价。
DOI：
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发表时间：
1983
影响因子：
9.8
通讯作者：
M. Forsgren
中科院分区：
文献类型：
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作者：
G. Larsson;C. Ottenblad;L. Hagenfeldt;A. Larsson;M. Forsgren
本文分析了669例孕妇血清γ-谷氨酰转移酶的变化。他们接受了采访，特别强调了他们在头三个月的酒精消费。13%的人承认每天纯酒精消费量超过30克，3%的人承认每天纯酒精消费量超过125克。一个孩子与一个完整的胎儿酒精综合征和一个部分的母亲与高消费的酒精和血清γ-谷氨酰转移酶升高。低消费者（每天饮酒少于30克）女性血清γ-谷氨酰转移酶的第95百分位数为0.44 mukat/L。以这个95%的特异性水平作为临界值，血清γ-谷氨酰转移酶试验在识别那些每天饮酒超过30克的人中的灵敏度为25%。结论是，基于血清γ-谷氨酰转移酶分析的筛查不推荐在产前护理中常规使用。
Serum gamma-glutamyl transferase was analyzed in 669 pregnant women. They were interviewed with special emphasis on their consumption of alcohol during the first trimester. Thirteen percent admitted a consumption of greater than 30 gm of pure alcohol per day, and 3%, greater than 125 gm per day. One child with a complete fetal alcohol syndrome and one with a partial one were born to mothers with a high consumption of alcohol and elevated serum gamma-glutamyl transferase. The ninety-fifth percentile for serum gamma-glutamyl transferase in women classified as low consumers (less than 30 gm of alcohol per day) was 0.44 mukat/L. With this 95% specificity level used as a cutoff, the sensitivity of the serum gamma-glutamyl transferase test in identifying those who consumed more than 30 gm of alcohol per day was 25%. The conclusion was that screening based on analyses of serum gamma-glutamyl transferase is not to be recommended for routine use in prenatal care.