Bacterial Iron Homeostasis Regulation by sRNAs
Bacterial Iron Homeostasis Regulation by sRNAs
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DOI：
10.1128/microbiolspec.rwr-0010-2017
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发表时间：
2018-04-01
影响因子：
3.7
通讯作者：
Mandin, Pierre
中科院分区：
文献类型：
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作者：
Chareyre, Sylvia;Mandin, Pierre
虽然铁是维持生长所必需的，但其过量可能会通过产生高毒性的活性氧对细胞有害。因此，铁稳态的调节在几乎所有生物体中起着至关重要的作用。在过去的15年中，小RNA（sRNA）RyhB已被证明是细菌铁稳态调节的关键因素。通过多种分子机制，RyhB抑制消耗性铁利用蛋白，促进铁载体的产生，并协调Fe-S簇辅因子生物合成，从而建立所谓的铁节约反应。本文主要通过对大肠杆菌中RyhB的研究，对sRNA调控铁稳态的机制进行综述。还将描述其他sRNA在不同细菌中的平行作用和作用模式。最后，我们将讨论什么问题仍然有待回答这个重要的应激反应调节sRNAs。
While iron is essential to sustain growth, its excess can be detrimental to the cell by generating highly toxic reactive oxygen species. Regulation of iron homeostasis thus plays a vital role in almost all living organisms. During the last 15 years, the small RNA (sRNA) RyhB has been shown to be a key actor of iron homeostasis regulation in bacteria. Through multiple molecular mechanisms, RyhB represses expendable iron-utilizing proteins, promotes siderophore production, and coordinates Fe-S cluster cofactor biogenesis, thereby establishing a so-called iron-sparing response. In this review, we will summarize knowledge on how sRNAs control iron homeostasis mainly through studies on RyhB in Escherichia coli. The parallel roles and modes of action of other sRNAs in different bacteria will also be described. Finally, we will discuss what questions remain to be answered concerning this important stress response regulation by sRNAs.