The pathogenesis of cancer related fatigue: Could increased activity of pro-inflammatory cytokines be the common denominator?
The pathogenesis of cancer related fatigue: Could increased activity of pro-inflammatory cytokines be the common denominator?
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DOI：
10.1016/j.ejca.2007.11.023
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发表时间：
2008-01-01
影响因子：
8.4
通讯作者：
van der Rijt, C. C. D.
中科院分区：
文献类型：
--
作者：
Jager, A.;Sleijfer, S.;van der Rijt, C. C. D.
癌症相关疲劳（CRF）被定义为与癌症或癌症治疗相关的干扰日常功能的持续主观疲劳感，是癌症患者中非常普遍的，可能是最被低估和治疗不足的并发症。因此，揭示CRF的发病机制对于确定新的治疗靶点具有重要意义。一般认为，发病机制是多原因的，这解释了为什么大多数治疗干预只针对一个潜在的致病因素是不成功的。在这方面，令人感兴趣的是，促炎细胞因子活性的增加可能是导致CRF的共同因素。对促炎细胞因子活性增加在CRF中的核心作用的详细了解，有望通过影响贫血、下丘脑-垂体-肾上腺轴紊乱和脑血清素代谢改变等广泛的致病因素，为CRF的治疗提供有效的方法。(c) 2007 Elsevier Ltd.版权所有。
Cancer related fatigue (CRF), defined as a persistent subjective sense of tiredness related to cancer or cancer treatment that interferes with daily functioning, is highly prevalent and probably the most underestimated and insufficiently treated complication in cancer patients. Therefore, unravelling the pathogenesis of CRF is of great importance allowing the identification of novel therapeutic targets. It is generally believed that the pathogenesis is multicausal, explaining why most therapeutic interventions directed towards only one potential causative factor are unsuccessful. In this regard, it is of interest that increased activity of pro-inflammatory cytokines might be a common denominator causing CRF. Detailed insight in the central role of increased activity of pro-inflammatory cytokines in CRF will hopefully offer an effective approach in the treatment of CRF by affecting a broad array of proposed causative factors such as anaemia, disturbances of the hypothalamic-pituitary-adrenal axis and altered brain serotonin metabolism. (c) 2007 Elsevier Ltd. All rights reserved.