Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
Lrp4 domains differentially regulate limb/brain development and synaptic plasticity.
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DOI：
10.1371/journal.pone.0116701
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Herz J
中科院分区：
文献类型：
--
作者：
Pohlkamp T;Durakoglugil M;Lane-Donovan C;Xian X;Johnson EB;Hammer RE;Herz J
Apolipoprotein E (ApoE) genotype is the strongest predictor of Alzheimer’s Disease (AD) risk. ApoE is a cholesterol transport protein that binds to members of the Low-Density Lipoprotein (LDL) Receptor family, which includes LDL Receptor Related Protein 4 (Lrp4). Lrp4, together with one of its ligands Agrin and its co-receptors Muscle Specific Kinase (MuSK) and Amyloid Precursor Protein (APP), regulates neuromuscular junction (NMJ) formation. All four proteins are also expressed in the adult brain, and APP, MuSK, and Agrin are required for normal synapse function in the CNS. Here, we show that Lrp4 is also required for normal hippocampal plasticity. In contrast to the closely related Lrp8/Apoer2, the intracellular domain of Lrp4 does not appear to be necessary for normal expression and maintenance of long-term potentiation at central synapses or for the formation and maintenance of peripheral NMJs. However, it does play a role in limb development.
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影响因子：
16.2
作者：
Lane-Donovan, Courtney;Philips, Gary T.;Herz, Joachim
通讯作者：
Herz, Joachim
DOI：
10.1073/pnas.0908176106
发表时间：
2009-09-15
影响因子：
11.1
作者：
Durakoglugil, Murat S.;Chen, Ying;Herz, Joachim
通讯作者：
Herz, Joachim
影响因子：
5.3
作者：
Priller, Christina;Bauer, Thomas;Herms, Jochen
通讯作者：
Herms, Jochen
影响因子：
7.7
作者：
Choi HY;Liu Y;Tennert C;Sugiura Y;Karakatsani A;Kröger S;Johnson EB;Hammer RE;Lin W;Herz J
通讯作者：
Herz J
DOI：
10.1523/jneurosci.4872-08.2009
发表时间：
2009-06-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Hoe HS;Lee KJ;Carney RS;Lee J;Markova A;Lee JY;Howell BW;Hyman BT;Pak DT;Bu G;Rebeck GW
通讯作者：
Rebeck GW