¹H, ¹³C, and ¹⁵N chemical shift assignments of neuronal calcium sensor protein, hippocalcin.

¹H, ¹³C, and ¹⁵N chemical shift assignments of neuronal calcium sensor protein, hippocalcin.
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神经元钙传感器蛋白海马钙蛋白的 H、C 和 N 化学位移分配。

DOI:
10.1007/s12104-012-9453-3
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发表时间:
2014
影响因子:
0.9
通讯作者:
Ames,JamesB
Ames,JamesB
中科院分区:
生物学4区
文献类型:
--
作者:
Li,Congmin;Ames,JamesB

文献摘要

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海马钙素是钙调蛋白超家族神经元钙传感器 (NCS) 亚类的成员,是海马中缓慢后超极化 (sAHP) 电流的重要钙传感器,而海马是某些形式的学习和记忆的基础。海马钙素也是海马长期抑郁 (LTD) 的钙传感器,并且与神经退行性疾病存在遗传相关性。我们报告了不含 Ca2+ 的海马钙蛋白的 NMR 化学位移归属(BMRB 编号 18627)。
Hippocalcin, a member of the neuronal calcium sensor (NCS) subclass of the calmodulin superfamily, serves as an important calcium sensor for the slow afterhyperpolarizing (sAHP) current in the hippocampus, which underlies some forms of learning and memory. Hippocalcin is also a calcium sensor for hippocampal long-term depression (LTD) and genetically linked to neurodegenerative diseases. We report NMR chemical shift assignments of Ca2+-free hippocalcin (BMRB no. 18627).