Acoustic startle and prepulse inhibition in 40 inbred strains of mice.

Acoustic startle and prepulse inhibition in 40 inbred strains of mice.
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40 种近交系小鼠的声惊吓和前脉冲抑制。

DOI:
10.1037/0735-7044.117.4.716
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发表时间:
2003
影响因子:
1.9
通讯作者:
Gagnon,Leona
Gagnon,Leona
中科院分区:
医学4区
文献类型:
--
作者:
Willott,JamesF;Tanner,Lisa;O'Steen,Jennifer;Johnson,KennethR;Bogue,MollyA;Gagnon,Leona

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采用高通量表型筛选方法检测小鼠的声惊吓反应(ASR)和前脉冲抑制(PPI)。由噪声突发诱发ASR; PPI的前脉冲为4、12和20 kHz的70 dB声压级音调。测试了40个近交系小鼠(在大多数情况下,每个品系使用10只雄性和10只雌性)。ASR和PPI的数据有很高的内部和重测信度,并表现出很大的差异,近交系之间,表明强烈的遗传影响。先前获得的措施,听力灵敏度在同一近交系没有显着相关性与ASR或PPI措施。(PsycInfo数据库记录(c)2016阿帕,保留所有权利)
A high-throughput phenotype screening protocol was used to measure the acoustic startle response (ASR) and prepulse inhibition (PPI) in mice. ASRs were evoked by noise bursts; prepulses for PPI were 70 dB sound pressure level tones of 4, 12, and 20 kHz. Forty inbred strains of mice were tested (in most cases using 10 males and 10 females of each strain). The data on both the ASR and PPI had high internal and test-retest reliability and showed large differences among inbred strains, indicative of strong genetic influences. Previously obtained measures of hearing sensitivity in the same inbred strains were not significantly correlated with ASR or PPI measures.(PsycINFO Database Record (c) 2016 APA, all rights reserved)
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