"Tethered" Ru(II) catalysts for asymmetric transfer hydrogenation of ketones
"Tethered" Ru(II) catalysts for asymmetric transfer hydrogenation of ketones
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DOI：
10.1021/jo050032a
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发表时间：
2005-04-15
影响因子：
3.6
通讯作者：
Wills, M
中科院分区：
文献类型：
--
作者：
Cheung, FK;Hayes, AM;Wills, M
立体化学定义明确的钌（II）催化剂应用于一系列酮的不对称转移加氢反应。在一个案例中，采用统计实验设计来优化产品的对映体过量。在以tsdpen为基础的体系中，用顺式取代反式-1,2-二苯基取代，或删除其中一个苯基，会导致对映体过量的显著恶化。介绍了一种合成系链氨基醇催化剂的新方法。
Stereochemically well-defined ruthenium(II) catalysts have been applied to the asymmetric transfer hydrogenation of a series of ketones. In one case, statistical experimental design was employed to optimize the enantiomeric excess of the product. In the case of the TsDPEN-based systems, the replacement of trans-1,2-diphenyl substitution with cis-, or deletion of one of the phenyl groups, results in significant deterioration of the enantiomeric excess. A new method is described for the synthesis of tethered amino alcohol-containing catalysts.