Heterochromatin, position effects, and the genetic dissection of chromatin.
Heterochromatin, position effects, and the genetic dissection of chromatin.
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异染色质、位置效应和染色质的遗传解剖。
DOI：
10.1016/s0079-6603(03)01016-x
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Wallrath,LoriL
中科院分区：
文献类型：
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作者：
Eissenberg,JoelC;Wallrath,LoriL
The partitioning of the eukaryotic chromosome regions into heterochromatin and euchromatin reflects fundamental differences in the packaging of DNA. The observation that chromosome rearrangments juxtaposing euchromatic sequences with heterochromatic regions usually result in silencing of nearby euchromatic genes (termed “position effect silencing”) led to genetic screens for position effect modifiers. These screens uncovered key proteins involved in chromatin assembly, including structural components of heterochromatin and euchromatin, and enzymes that covalently modify histones. In addition, recent data implicates RNA in the targeting of chromosome regions for heterochromatin assembly. Here, we review the genetic, cytological, and biochemical properties of heterochromatin and summarize recent data suggesting mechanisms for heterochromatin assembly.
