Experimental validation of Monte Carlo dose calculations about a high-intensity Ir-192 source for pulsed dose-rate brachytherapy.
Experimental validation of Monte Carlo dose calculations about a high-intensity Ir-192 source for pulsed dose-rate brachytherapy.
复制标题
用于脉冲剂量率近距离放射治疗的高强度 Ir-192 源的蒙特卡罗剂量计算的实验验证。
DOI：
10.1118/1.597484
复制
发表时间：
1995
期刊：
影响因子：
3.8
通讯作者：
Williamson,JF
中科院分区：
文献类型：
--
作者：
Valicenti,RK;Kirov,AS;Meigooni,AS;Mishra,V;Das,RK;Williamson,JF
尽管高强度Ir-192远程后装源得到了广泛使用，但目前还没有针对当前使用的源设计的已发表的测量或计算剂量率表。对于脉冲剂量率Ir-192源，在固体水体模中使用热释光剂量测定法测量横轴（0.5-10 cm）和二维极剂量率分布（1.5、3和5 cm）。将剂量率标准化为测量的空气比释动能强度，并通过针孔放射自显影和透射射线照相验证源几何形状。在每个测量点，剂量率计算的Monte Carlo光子传输（MCPT）代码，它逼真地模拟了实验体模，源和探测器的几何形状。MCPT绝对剂量率计算和测量之间的一致性平均为3%，小于5%，这表明蒙特卡罗模拟是高活性Ir-192源二维剂量测定表征的准确且强大的工具。
Despite widespread use of high‐intensity Ir‐192 remotely afterloaded sources, no published measured or calculated dose‐rate tables for currently used source designs are available. For a pulsed dose‐rate Ir‐192 source, both transverse axis (0.5–10 cm) and two‐dimensional polar dose‐rate profiles (1.5, 3, and 5 cm) were measured with thermoluminescent dosimetry in a solid water phantom. Dose rates were normalized to measured air‐kerma strength, and the source geometry was verified by pinhole autoradiography and transmission radiography. At each measurement point, dose rates were calculated by a Monte Carlo photon transport (MCPT) code, which realistically modeled the experimental phantom, source, and detector geometry. Agreement between MCPT absolute dose‐rate calculations and measurements averaged 3% and was less than 5%, demonstrating that Monte Carlo simulation is an accurate and powerful tool for two‐dimensional dosimetric characterization of high activity Ir‐192 sources.