Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
Adipose tissue metabolites and insulin resistance in nondiabetic Asian Indian men
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DOI：
10.1210/jc.2003-031843
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发表时间：
2004-06-01
影响因子：
5.8
通讯作者：
Grundy, SM
中科院分区：
文献类型：
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作者：
Abate, N;Chandalia, M;Grundy, SM
肥胖相关的胰岛素抵抗与脂肪组织释放瘦素、脂联素和非酯化脂肪酸（NEFA）的变化有关。我们以前描述过，来自印度次大陆的人（亚洲印度人）即使没有肥胖症也表现出过度的胰岛素抵抗。因此，在这项研究中，我们测试的假设，即非糖尿病，胰岛素抵抗的亚洲印度人不同的相似年龄和身体成分的胰岛素抵抗较少的白人在脂肪组织生产的瘦素和脂联素，并在抑制血浆NEFA浓度在高胰岛素血症。79名亚洲印度男性与61名白人男性进行了比较。亚洲印度人较高的血浆NEFAs和瘦素（NEFAs和瘦素分别为P < 0.0001和P = 0.003）和较低的血浆脂联素浓度（P = 0.009）不能用体脂含量和分布来解释。口服葡萄糖耐量试验研究显示，白人男性比亚洲印度男性对血浆NEFA的抑制更大。我们的结论是，与胰岛素敏感的高加索人相比，胰岛素抵抗的亚洲印度人的脂肪组织代谢产物瘦素和NEFA的血浆浓度较高，脂联素的血浆浓度较低。这些差异可能导致非肥胖亚洲印度人2型糖尿病和心血管疾病的过度流行。
Obesity-related insulin resistance is associated with changes in adipose tissue release of leptin, adiponectin, and nonesterified fatty acids (NEFAs). We have previously described that persons originating from the Indian subcontinent ( Asian Indians) manifest excessive insulin resistance even in the absence of obesity. Therefore, in this study, we tested the hypothesis that nondiabetic, insulin-resistant Asian Indians differ from less insulin-resistant Caucasians of similar age and body composition in adipose tissue production of leptin and adiponectin, and in suppression of plasma NEFA concentrations during hyperinsulinemia. Seventy-nine Asian Indian men were compared with 61 Caucasian men. Higher plasma NEFAs and leptin in Asian Indians ( P < 0.0001 and P = 0.003 for NEFAs and leptin, respectively) and lower plasma concentrations of adiponectin ( P = 0.009) were not explained by body fat content and distribution. Oral glucose tolerance test studies revealed that Caucasian men had greater suppression of plasma NEFAs than Asian Indian men. We conclude that plasma concentrations of the adipose tissue metabolites leptin and NEFAs are higher and that of adiponectin is lower in insulin-resistant Asian Indians compared with more insulin-sensitive Caucasians. These differences may contribute to the excessive prevalence of type 2 diabetes and cardiovascular disease in nonobese Asian Indians.