Evaluation of the EORTC QLQ-C30 questionnaire: A comparison with SF-36 Health Survey in a cohort of Italian long-survival cancer patients
Evaluation of the EORTC QLQ-C30 questionnaire: A comparison with SF-36 Health Survey in a cohort of Italian long-survival cancer patients
复制标题
DOI：
10.1023/a:1008264412398
复制
发表时间：
1998-05-01
影响因子：
50.5
通讯作者：
Mosconi, P
中科院分区：
文献类型：
--
作者：
Apolone, G;Filiberti, A;Mosconi, P
背景资料：尽管有大量的数据可用于EORTC QLQ-C30问卷，有很少的研究集中在长期生存的癌症患者，并没有数据可用于其性能在意大利设置。方法.在一个旨在评价可用意大利语HR-QOL问卷特征的项目框架内，将EORTC QLQ-C30问卷和简表36项健康调查（SF-36）邮寄给先前在两项关于早期乳腺癌和结肠癌的大型多中心随机临床试验中招募的患者样本。采用标准的心理测量技术和人口统计学和临床独立变量的相关分析对问卷的性质进行评估。在发回评估问卷的患者样本中，EORTC QLQ-C30显示出令人满意的可接受性（应答率= 64%，项目和量表水平的缺失率非常低），心理测量学分析证实了聚合效度和判别效度方面的多维概念化。此外，EORTC QLQ-C30量表与同源SF-36量表具有显著相关性。很少有社会人口统计学（年龄，性别，学校教育）和临床（癌症疾病类型）变量与HR-QOL相关。乳腺癌患者的报告，平均：较差的身体健康相关的分数，但调整后的年龄和教育，大部分的差异消失了。结论：这些研究结果证实了EORTC QLQ-C30在这个样本中的有效性和鲁棒性的长期生存的意大利癌症患者。需要进一步的专门验证研究来评估其在这些特定患者中的意义。
Background: Despite the large amount of data available about the EORTC QLQ-C30 questionnaire, there have been very few studies focussed on long-survival cancer patients, and no data are available on its performance in the Italian setting.Patients and il?methods. Within the framework of a project aimed at evaluating the characteristics of available HR-QOL questionnaires in the Italian language, the EORTC QLQ-C30 questionnaire together with the Short Form 36-item Health Survey (SF-36) were mail-administered to a sample of patients previously recruited in two large multicenter randomized clinical trials on early breast and colon cancers. The properties of the questionnaire were evaluated using standard psychometric techniques and correlation analyses with demographic and clinical independent variables.Results. In the sample of patients who sent back the questionnaires under evaluation, the EORTC QLQ-C30 showed satisfactory acceptability (response rate = 64% and very low prevalence of missing at item and scale level), and the psychometric analyses confirmed the multi-dimensional conceptualisation in terms of convergent and discriminant validity. Moreover, EORTC QLQ-C30 scales showed substantial correlation with the homologous SF-36 scales. Few socio-demographic (age, gender, schooling) and clinical (type of cancer disease) variables were associated with HR-QOL. Breast cancer patients reported, on average: worse physical health-related scores, but after adjustment for age and education, most of the differences disappeared.Conclusions: These findings confirm the validity and robustness of the EORTC QLQ-C30 in this sample of long-survival Italian cancer patients. Further ad hoc validation studies are required to evaluate its significance in these particular patients.