Quantitative analysis of neurophysiological processes of the aging CNS
Quantitative analysis of neurophysiological processes of the aging CNS
复制标题
衰老中枢神经系统神经生理过程的定量分析
DOI：
10.1007/bf00313013
复制
发表时间：
1978
影响因子：
6
通讯作者：
F. Drechsler
中科院分区：
文献类型：
--
作者：
F. Drechsler
对 65 名老年受试者（62-91 岁）和 48 名对照受试者（18-38 岁）进行了电生理学研究。老年人脑电图的功率谱表现出不同的类型，从具有明显的α活动峰值的谱到不同步型的谱。在老年受试者中发现枕叶阿尔法节律的周期性逐渐恶化，并且两个枕叶活动之间的时间逐渐偏移。 SEP 和 VEP 会延长所有组件的延迟。 SEP 所有分量的幅度均显着增加，而 VEP 的幅度在正常范围内。优势半球的参与更为显着。 SEP 的经胼胝体传输本质上不涉及。从数量上看，某些 SEP 组件的传输持续时间显着延长。 SEP 从特定皮质反应区域到同侧半球不同区域的传输显着增加。据推测，在衰老过程中，皮质神经元递质机制参与其中，并且特定皮质抑制过程逐渐减少。
Electrophysiological studies were performed on 65 aged subjects (62–91 years) and 48 control subjects (18–38 years). The power spectrum of the EEG in the aging persons shows different types, from spectra with a marked peak of alpha activity to spectra of a desynchronized type. Progressive deterioration of the periodicity of the occipital alpha rhythm and also a progressive time shift between the activities of both occipital lobes were found in the aging subjects. The SEP and VEP have prolonged latencies of all components. The amplitudes of all components of the SEP are significantly increased and those of the VEP are within normal limits. There is a more significant involvement of the dominant hemisphere. Transcallosal transmission of the SEP is qualitatively not involved. Quantitatively there is a marked prolongation of the duration of the transmission of certain SEP components. Transmission of the SEP from the specific cortical response area to different areas of the ipsilateral hemisphere is significantly increased. It is assumed that during aging there is an involvement of the cortical neuronal transmitter mechanisms and a progressive decrease of the specific cortical inhibitory processes.