Molecular Structure and Diversity of PBAN/pyrokinin Family Peptides in Ants.
Molecular Structure and Diversity of PBAN/pyrokinin Family Peptides in Ants.
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DOI：
10.3389/fendo.2012.00032
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发表时间：
2012
影响因子：
5.2
通讯作者：
Vander Meer RK
中科院分区：
文献类型：
--
作者：
Choi MY;Vander Meer RK
神经肽是昆虫激素中最大的一类。它们在中枢和外周神经系统中产生，影响昆虫的发育、生殖、摄食和行为。在昆虫中已经鉴定出多种神经肽家族。这些家族之一是PBAN/焦激肽家族，其由C末端的共同FXPRL酰胺或类似氨基酸片段定义。这些肽在迄今为止研究的所有昆虫中发现，在整个进化过程中一直是保守的。研究最多的生理功能是通过信息素生物合成激活神经肽（PBAN）调节蛾性信息素的生物合成，尽管也有一些发育功能的报道。在过去的几年里，我们已经扩展了PBAN/pyrokinin家族的肽的知识，蚂蚁，主要集中在火蚁，红火蚁。火蚁是研究最多的社会昆虫之一，在过去的60年里，人们对这种蚂蚁的许多方面都有了很多了解，包括信息素通信的行为和化学。然而，几乎没有人知道这些信息素系统的调节。最近，我们证明了存在的PBAN/pyrokinin免疫反应神经元的火蚂蚁，并确定和特点PBAN和其他神经肽。我们绘制了火蚁PBAN基因结构图，并测定了其在中枢神经系统中的组织表达水平。我们在这里回顾我们的研究，迄今为止的蚂蚁PBAN/pyrokinin肽的分子结构和多样性的准备，以确定在蚂蚁和其他社会昆虫的神经肽的功能。
Neuropeptides are the largest group of insect hormones. They are produced in the central and peripheral nervous systems and affect insect development, reproduction, feeding, and behavior. A variety of neuropeptide families have been identified in insects. One of these families is the PBAN/pyrokinin family defined by a common FXPRLamide or similar amino acid fragment at the C-terminal end. These peptides, found in all insects studied thus far, have been conserved throughout evolution. The most well studied physiological function is regulation of moth sex pheromone biosynthesis through the pheromone biosynthesis activating neuropeptide (PBAN), although several developmental functions have also been reported. Over the past years we have extended knowledge of the PBAN/pyrokinin family of peptides to ants, focusing mainly on the fire ant, Solenopsis invicta. The fire ant is one of the most studied social insects and over the last 60 years a great deal has been learned about many aspects of this ant, including the behaviors and chemistry of pheromone communication. However, virtually nothing is known about the regulation of these pheromone systems. Recently, we demonstrated the presence of PBAN/pyrokinin immunoreactive neurons in the fire ant, and identified and characterized PBAN and additional neuropeptides. We have mapped the fire ant PBAN gene structure and determined the tissue expression level in the central nervous system of the ant. We review here our research to date on the molecular structure and diversity of ant PBAN/pyrokinin peptides in preparation for determining the function of the neuropeptides in ants and other social insects.