Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study
Association of cholesterol uptake capacity, a novel indicator for HDL functionality, and coronary plaque properties: An optical coherence tomography-based observational study
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DOI：
10.1016/j.cca.2020.01.001
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发表时间：
2020-04-01
影响因子：
5
通讯作者：
Hirata, Ken-ichi
中科院分区：
文献类型：
--
作者：
Oshita, Toshihiko;Toh, Ryuji;Hirata, Ken-ichi
背景：动脉粥样硬化病变的胆固醇流出是高密度脂蛋白（HDL）的重要功能。最近，我们建立了一种简单、高通量、无细胞的方法来评估HDL接受额外胆固醇的能力，在本文中被称为“胆固醇摄取能力（CUC）"。目的：阐明CUC与冠状动脉斑块性质之间的横截面关系。我们招募了135名患者，通过光学相干断层扫描（OCT）测量CUC并评估血管造影狭窄的形态学特征。我们通过将平均脂质弧乘以脂质长度（脂质指数）来估计富脂斑块的范围。OCT检测到的巨噬细胞在靶斑块中积聚的程度采用分级系统进行半定量估计。结果：125例患者（92.6%）发现富含脂质的斑块病变。CUC与血脂指数呈负相关（R =-0.348，P < 0.0001）。CUC与巨噬细胞评分呈负相关（R =-0.327，P < 0.0001）。相反，无论是循环水平的高密度脂蛋白胆固醇，也没有载脂蛋白A1表现出类似的relationship.Conclusions：我们证明，CUC是负相关的脂质丰富的斑块负担和巨噬细胞积累的程度，这表明CUC可能是有用的心血管危险分层。
Background: Cholesterol efflux from atherosclerotic lesion is a key function of high-density lipoprotein (HDL). Recently, we established a simple, high-throughput, cell-free assay to evaluate the capacity of HDL to accept additional cholesterol, which is herein referred to as "cholesterol uptake capacity (CUC)".Objective: To clarify the cross-sectional relationship between CUC and coronary plaque properties.Methods: We enrolled 135 patients to measure CUC and assess the morphological features of angiographic stenosis by optical coherence tomography (OCT). We estimated the extent of the lipid-rich plaque by multiplying the mean lipid arc by lipid length (lipid index). The extent of the OCT-detected macrophage accumulation in the target plaque was semi-quantitatively estimated using a grading system.Results: Lipid-rich plaque lesions were identified in 125 patients (92.6%). CUC was inversely associated with the lipid index (R = -0.348, P < 0.0001). In addition, CUC was also inversely associated with macrophage score (R = - 0.327, P < 0.0001). Conversely, neither circulating levels of HDL cholesterol nor apoA1 showed a similar relationship.Conclusions: We demonstrated that CUC was inversely related to lipid-rich plaque burden and the extent of macrophage accumulation, suggesting that CUC could be useful for cardiovascular risk stratification.